Higher serum lipids and oxidative stress in patients with normal tension glaucoma, but not pseudoexfoliative glaucoma


  • Necat Yilmaz Department of Clinical Biochemistry, Central Laboratories of Antalya Training and Research Hospital, Antalya, Turkey,
  • Deniz Turgut Coban Department of Ophthalmology, Antalya Training and Research Hospital, Antalya, Turkey
  • Asli Bayindir Department of Clinical Biochemistry, Central Laboratories of Antalya Training and Research Hospital, Antalya, Turkey,
  • Muhammet Kazım Erol Department of Ophthalmology, Antalya Training and Research Hospital, Antalya, Turkey
  • Hamit Yasar Ellidag Department of Clinical Biochemistry, Central Laboratories of Antalya Training and Research Hospital, Antalya, Turkey,
  • Ozlem Giray Department of Clinical Biochemistry, Central Laboratories of Antalya Training and Research Hospital, Antalya, Turkey,
  • Suha Sayrac Research and Development Unit, Antalya Association of Public Hospitals, Antalya, Turkey
  • Seckin Ozgur Tekeli Department of Clinical Biochemistry, Central Laboratories of Antalya Training and Research Hospital, Antalya, Turkey
  • Esin Eren Department of Clinical Biochemistry, Central Laboratories of Antalya Training and Research Hospital, Antalya, Turkey




Oxidative Stress, Paraoxonase, High-Density Lipoprotein, Hyperlipidemia, Normal Tension Glaucoma, Pseudoexfoliative Glaucoma, PON1 Phenotype


This study entailed a cross-examination of oxidant/antioxidant balance, high-density lipoprotein (HDL)-linked paraoxonase 1 (PON1) phenotypes, and levels of serum routine lipids among patients with normal tension glaucoma (NTG) or pseudoexfoliative glaucoma (PEXG) compared with healthy control groups. We aimed to investigate the links between oxidative stress (OS), HDL-related antioxidant enzyme activities and dyslipidemia in distinct subtypes of glaucoma. The study included 32 patients with NTG, 31 patients with PEXG, and 40 control subjects. Levels of PON1 and arylesterase enzymatic activity, total oxidant status (TOS), and total antioxidant status were measured by spectrophotometry and OS indexes (OSI) were calculated. The phenotype distribution of PON1 was determined using the dual substrate method. Blood serum levels of HDL, low-density lipoprotein, total cholesterol (TC), and triglyceride (TG) were measured. The TOS and OSI values in the NTG group were significantly higher compared with the other groups (both p < 0.01). The phenotype distribution found in the glaucoma and control groups were NTG: QQ, 59.4%; QR, 37.5%; RR, 3.1%; PEXG: QQ, 45.1%; QR, 48.4%; RR, 6.5%; and in the control group: QQ, 42.5%; QR, 50.0%; RR, 7.5%. Serum TC levels were significantly higher than the control in both NTG and PEXG groups, whereas TG was significantly higher in NTG only (p < 0.01 and p < 0.02, respectively). Hyperlipidemia, OS and variations in phenotype distribution of PON1 may play a role in the pathogenesis of different types of glaucoma.


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Higher serum lipids and oxidative stress in patients with normal tension glaucoma, but not pseudoexfoliative glaucoma


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Higher serum lipids and oxidative stress in patients with normal tension glaucoma, but not pseudoexfoliative glaucoma. Biomol Biomed [Internet]. 2016 Jan. 1 [cited 2024 Apr. 22];16(1):21-7. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/830