Anti-inflammatory role of fenofibrate in treating diseases

Authors

  • Lv Jin Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China
  • Hu Hua Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China; Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China
  • Yong Ji Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China; Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China
  • Zhanjun Jia Department of Nephrology, Children’s Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, China; Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China
  • Mingqi Peng Nursing Department, Children’s Hospital of Nanjing Medical University, Nanjing, China
  • Songming Huang Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China; Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China

DOI:

https://doi.org/10.17305/bb.2022.8534

Keywords:

Fenofibrate, inflammation, mechanism, PPAR-α, diseases, therapy

Abstract

Inflammation contributes to the pathogenesis of several diseases. Fenofibrate, known as a peroxisome proliferator-activated receptor - α (PPAR-α) agonist, is a classic drug for treating hyperlipidemia. In addition to its lipid-lowering effect, fenofibrate has also been reported to exert anti-inflammatory effects with complicated underlying mechanisms of action. In general, the anti-inflammatory effect of fenofibrate is secondary to its lipid-lowering effect, especially for the inflammation caused by hyperlipidemia in the circulatory system. Some anti-inflammatory actions may also come from its regulatory effects on intracellular lipid metabolism by activating PPAR-α. In addition, some roles in anti-inflammation might be mediated by its direct regulation of inflammatory signaling pathways. In order to understand anti-inflammatory activities and the underlying mechanisms of fenofibrate action in disease better, we herein reviewed and discussed the anti-inflammatory roles and its subserving mechanisms in various diseases of different organ systems. Thus, this review offers insights into the optimal use of fenofibrate in the clinical setting.

Anti-inflammatory role of fenofibrate in treating diseases

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Published

01-05-2023

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How to Cite

1.
Anti-inflammatory role of fenofibrate in treating diseases. Biomol Biomed [Internet]. 2023 May 1 [cited 2024 Feb. 26];23(3):376–391. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/8534