Etiology and clinical features of non-O1/non-O139 Vibrio cholerae infection in an inland city in China

Authors

  • Yu-Han Xiang Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, China https://orcid.org/0000-0002-0202-7042
  • Qin-Qin Hu Nursing Department, Affiliated Hospital of Jining Medical University, Jining, China https://orcid.org/0000-0001-7316-1575
  • Yan Liu Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, China https://orcid.org/0000-0003-3001-1512
  • Rui Sheng Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, China https://orcid.org/0000-0002-0772-1439
  • Jie Wang Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, China
  • Wen-Jing Li School of Clinical Medicine, Jining Medical University, Jining, China https://orcid.org/0000-0002-5839-524X
  • Jian Shi School of Clinical Medicine, Jining Medical University, Jining, China
  • Xue Li School of Clinical Medicine, Jining Medical University, Jining, China
  • Shu-Hua Lu Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, China https://orcid.org/0000-0003-3099-2461

DOI:

https://doi.org/10.17305/bb.2022.8745

Keywords:

Non-O1/non-O139 Vibrio cholerae, Vibrio cholerae, infection, bacteremia, antimicrobial susceptibility

Abstract

Non-O1/non-O139 Vibrio cholerae (NOVC) causes various illnesses ranging in severity from mild to life-threatening but were ignored previously. Knowledge of the NOVC infection, particularly bacteremia, is limited because of its rarity. Here we first retrospectively reported the demographic, clinical, and therapy characteristics of patients with NOVC infection. Isolated NOVC stains were identified by a series of biochemical, mass spectrometry (MS), and serum agglutination tests. The results of 11 patients with NOVC infection (including 8 with bacteremia) with a median age of 68 years were included in this report. Most isolated NOVC strains had antibiotic susceptibility. Patients with NOVC-positive were distributed in various departments, most occurring in gastroenterology (6 cases). Hepatic disease was the most common comorbid disease, followed by diabetes (3 cases) and biliary tract disease (3 cases). Two cases were previously healthy. The most common symptom at presentation was fever. All patients presented with abnormal changes in hematology and inflammatory parameters. Cephalosporins were the most frequently used antibiotics. Ten patients had a favorable outcome after treatment; one died from complicated underlying diseases. In summary, we recommend the timely identification of NOVC strains using MALDI-TOF-MS. The suspicion of NOVC bacteremia cannot be ruled out regardless of the host’s immune status. An alternative therapeutic regimen for this infection may be β-lactam antibiotics or combined with β-lactamase inhibitors. Regardless, the specific therapeutic regimen should be based on the antibiogram data.

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Author Biographies

  • Wen-Jing Li, School of Clinical Medicine, Jining Medical University, Jining, China

     

     

  • Jian Shi, School of Clinical Medicine, Jining Medical University, Jining, China

     

     

  • Xue Li, School of Clinical Medicine, Jining Medical University, Jining, China

     

     

Etiology and clinical features of non-O1/non-O139 Vibrio cholerae infection in an inland city in China

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Published

03-07-2023

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Section

Translational and Clinical Research

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How to Cite

1.
Etiology and clinical features of non-O1/non-O139 Vibrio cholerae infection in an inland city in China. Biomol Biomed [Internet]. 2023 Jul. 3 [cited 2024 May 20];23(4):698–704. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/8745