Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use

Authors

  • Saif Badran Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar https://orcid.org/0000-0002-5955-1734
  • Suhail A. Doi Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar https://orcid.org/0000-0002-2630-2125
  • Atalla Hammouda Department of Plastic Surgery, Hamad General Hospital, Doha, Qatar
  • Omran A. H. Musa Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar https://orcid.org/0000-0001-6878-4364
  • Abdella M. Habib Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar https://orcid.org/0000-0001-7453-3932

DOI:

https://doi.org/10.17305/bb.2022.8807

Keywords:

Diabetes mellitus, oral glucose tolerance test (GTT), weighted average glucose, Doi’s weighted average glucose (dwAG), under the curve, homeostatic model assessment for insulin sensitivity (HOMA-S)

Abstract

In this study, we examined the performance of a novel index of glucose excursion (Doi’s weighted average glucose [dwAG]) in relation to the conventional measure of area under the oral glucose tolerance test (A-GTT) and the homeostatic model assessment for insulin sensitivity (HOMA-S) and pancreatic beta cell function (HOMA-B). A cross-sectional comparison of the new index was conducted using 66 oral glucose tolerance tests (GTTs) performed at different follow-up times among 27 participants who had undergone surgical subcutaneous fat removal (SSFR). Comparisons across categories were made using box plots and the Kruskal-Wallis one-way ANOVA on ranks. Passing-Bablok regression was used to compare the dwAG against the conventional A-GTT. The Passing-Bablok regression model suggested a cutoff for normality for the A-GTT of 15.14 mmol/L·2h-1 compared to the dwAG’s suggested threshold of 6.8 mmol/L. For every 1 mmol/L·2h-1 increase in A-GTT, the dwAG value increased by 0.473 mmol/L. The glucose area under the curve correlated well with the four defined dwAG categories, with at least one of the categories having a different median A-GTT value (KW Chi2 = 52.8 [df = 3], P < 0.001). The HOMA-S tertiles were also associated with significantly different levels of glucose excursion measured through both the dwAG value (KW Chi2 = 11.4 [df = 2], P = 0.003) and A-GTT measure (KW Chi2 = 13.1 [df = 2], P = 0.001). It is concluded that the dwAG value and categories serve as a simple and accurate tool that can be used for interpreting glucose homeostasis across clinical settings. 

Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use

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Published

04-09-2023

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New and Emerging Methods

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How to Cite

1.
Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use. Biomol Biomed [Internet]. 2023 Sep. 4 [cited 2024 Feb. 26];23(5):914–919. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/8807