Serum irisin correlates to the severity of acute myocardial infarction and predicts the postoperative major adverse cardiovascular events

Authors

  • Qiaoying Chai Department of Cardiology, The First Hospital of Handan, Handan, China
  • Wei Zhang Department of Cardiology, The First Hospital of Handan, Handan, China
  • Lijuan Gao Department of Cardiology, The First Hospital of Handan, Handan, China
  • Yingtao Yang Department of Cardiology, The First Hospital of Handan, Handan, China
  • Shuanli Xin Department of Cardiology, The First Hospital of Handan, Handan, China https://orcid.org/0000-0003-0882-105X

DOI:

https://doi.org/10.17305/bb.2023.8888

Keywords:

Acute myocardial infarction (AMI), percutaneous coronary intervention (PCI), major adverse cardiovascular events (MACE), irisin, ROC curve

Abstract

Irisin is a myogenic cytokine which plays an important role in the cardiovascular system. The aim of this study was to investigate the correlation between serum irisin levels and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). A total of 207 patients with AMI who underwent PCI were selected as research subjects. Serum irisin levels at admission were measured, and patients were stratified according to the receiver operating characteristic curve to assess differences in MACE within one year after PCI. After one year of follow-up, 207 patients were divided into two groups, 86 with MACE and 121 without MACE. There were significant differences in age, Killip grade, left ventricular ejection fraction, cardiac troponin I, creatine kinase-muscle/brain, and serum irisin between the two groups. Serum irisin level at admission in AMI patients significantly correlated with the occurrence of MACE after PCI, and could be used as an effective marker for predicting the occurrence of MACE in AMI patients after PCI.

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Author Biographies

  • Qiaoying Chai, Department of Cardiology, The First Hospital of Handan, Handan, China

     

     

     

  • Wei Zhang, Department of Cardiology, The First Hospital of Handan, Handan, China

     

     

     

  • Lijuan Gao, Department of Cardiology, The First Hospital of Handan, Handan, China

     

     

     

  • Yingtao Yang, Department of Cardiology, The First Hospital of Handan, Handan, China

     

     

     

  • Shuanli Xin, Department of Cardiology, The First Hospital of Handan, Handan, China

     

     

     

Serum irisin correlates to the severity of acute myocardial infarction and predicts the postoperative major adverse cardiovascular events

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Published

04-09-2023

Issue

Section

Biochemistry

Categories

How to Cite

1.
Serum irisin correlates to the severity of acute myocardial infarction and predicts the postoperative major adverse cardiovascular events. Biomol Biomed [Internet]. 2023 Sep. 4 [cited 2024 Apr. 25];23(5):785–791. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/8888