The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease

Authors

  • Fengyuan Duan Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, China; Kunming Kingmed Institute for Clinical Laboratory Co., Ltd., Kunming, China https://orcid.org/0000-0003-2399-8822
  • Zengqing Du Infectious Disease Department, Kunming Children's Hospital, Kunming, China
  • Yang Wang Clinical Laboratory, Yan'an Hospital of Kunming City, Kunming, China
  • Lan Luo Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, China
  • Lijiang Du Infectious Disease Department, Kunming Children's Hospital, Kunming, China
  • Hong Jiang Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, China
  • Yantuanjin Ma Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, China
  • Yuling Yang Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, China

DOI:

https://doi.org/10.17305/bb.2023.8948

Keywords:

Hand-foot-and-mouth disease, genetic polymorphism, EV71, SELPLG, SCARB2

Abstract

The same viral infection in different hosts may result in varying levels of clinical symptoms, which is related to the genetic background of the host itself. A total of 406 common cases and 452 severe cases of enterovirus 71 (EV71) infection in Yunnan Province were selected as the research subjects, and SNaPshot technology was used to detect genetic polymorphisms for 25 Tag single-nucleotide polymorphisms (TagSNPs) in the selectin P ligand (SELPLG) and scavenger receptor class B member 2 (SCARB2) genes. Our results demonstrate that SCARB2 polymorphisms (rs74719289, rs3733255 and rs17001551) are related to the severity of EV71 infection (A vs G: OR 0.330; 95% CI 0.115 - 0.947; T vs C: OR 0.336; 95% CI 0.118 - 0.958; and A vs G: OR 0.378; 95% CI 0.145 - 0.984). The SELPLG polymorphisms were not significantly different between common cases and severe cases. Therefore, we conclude that the SCARB2 gene has a protective effect on the course of hand, foot and mouth disease caused by EV71 infection and that SCARB2 gene mutations can reduce the severity of the disease.

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Author Biographies

  • Fengyuan Duan, Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, China; Kunming Kingmed Institute for Clinical Laboratory Co., Ltd., Kunming, China

     

     

     

     

     

     

     

     

  • Zengqing Du, Infectious Disease Department, Kunming Children's Hospital, Kunming, China

     

     

     

     

  • Yang Wang, Clinical Laboratory, Yan'an Hospital of Kunming City, Kunming, China

     

     

     

     

  • Lan Luo, Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, China

     

     

     

     

  • Lijiang Du, Infectious Disease Department, Kunming Children's Hospital, Kunming, China

     

     

     

     

  • Hong Jiang, Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, China

     

     

     

     

  • Yantuanjin Ma, Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, China

     

     

     

     

  • Yuling Yang, Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, China

     

     

     

     

 The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease

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Published

04-09-2023

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Section

Molecular Biology

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How to Cite

1.
The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease. Biomol Biomed [Internet]. 2023 Sep. 4 [cited 2024 Apr. 14];23(5):815–824. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/8948