S1P/S1PR signaling pathway advancements in autoimmune diseases

Authors

  • Jianbin Li Department of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, China https://orcid.org/0000-0001-9629-8558
  • Yiping Huang Department of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, China https://orcid.org/0000-0002-6072-8533
  • Yueqin Zhang Department of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, China
  • Pengcheng Liu Department of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, China https://orcid.org/0000-0002-9144-1623
  • Mengxia Liu Department of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, China
  • Min Zhang Department of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, China
  • Rui Wu Department of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, China

DOI:

https://doi.org/10.17305/bb.2023.9082

Keywords:

Sphingosine-1-phosphate (S1P), sphingosine-1-phosphate receptor (S1PR), S1P/S1PR signaling pathway, autoimmune diseases, research progress

Abstract

Sphingosine-1-phosphate (S1P) is a versatile sphingolipid that is generated through the phosphorylation of sphingosine by sphingosine kinase (SPHK). S1P exerts its functional effects by binding to the G protein-coupled S1P receptor (S1PR). This lipid mediator plays a pivotal role in various cellular activities. The S1P/S1PR signaling pathway is implicated in the pathogenesis of immune-mediated diseases, significantly contributing to the functioning of the immune system. It plays a crucial role in diverse physiological and pathophysiological processes, including cell survival, proliferation, migration, immune cell recruitment, synthesis of inflammatory mediators, and the formation of lymphatic and blood vessels. However, the full extent of the involvement of this signaling pathway in the development of autoimmune diseases remains to be fully elucidated. Therefore, this study aims to comprehensively review recent research on the S1P/S1PR axis in diseases related to autoimmunity.

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S1P/S1PR signaling pathway advancements in autoimmune diseases

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Published

03-11-2023

How to Cite

1.
S1P/S1PR signaling pathway advancements in autoimmune diseases. Biomol Biomed [Internet]. 2023 Nov. 3 [cited 2024 Jun. 15];23(6):922–935. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/9082