Prognostic value of a level of decrease in mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR) for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: an observational study

Authors

  • Emir Bećirović Internal Medicine Clinic, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina https://orcid.org/0000-0002-4134-987X
  • Kenana Ljuca School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina; Health Center of Sarajevo Canton, Sarajevo, Bosnia and Herzegovina https://orcid.org/0009-0004-9478-3284
  • Minela Bećirović Internal Medicine Clinic, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina https://orcid.org/0009-0007-4391-5226
  • Nadina Ljuca School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina
  • Mugdim Bajrić Department of Cardiovascular SurgeryDepartment of Cardiovascular Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina
  • Ammar Brkić Internal Medicine Clinic, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina https://orcid.org/0000-0002-5436-3670
  • Farid Ljuca Department of Physiology, School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina https://orcid.org/0000-0003-1143-1941

DOI:

https://doi.org/10.17305/bb.2023.9178

Keywords:

Mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR), major adverse cardiovascular events (MACE), myocardial infarction without ST-segment elevation

Abstract

The current study aimed to explore whether the level of decrease in platelet distribution width (PDW), platelet large cell ratio (P-LCR), and mean platelet volume (MPV) has prognostic value for major adverse cardiovascular events (MACEs) in acute myocardial infarction without ST-segment elevation (NSTEMI) treated by clopidogrel. In this prospective observational cohort study, PDW, P-LCR, and MPV were determined on admission at the hospital and 24 hours after clopidogrel treatment in 170 non-STEMI patients. MACEs were assessed over a one-year follow-up period. Using the Cox regression test, a decrease in PDW showed a significant association with the incidence of MACEs (OR 0.82, 95% CI 0.66-0.99, p=0.049) and overall survival rate (OR 0.95, 95% CI=0.91-0.99, p=0.016). Patients with a decrease in PDW<9.9% had a higher incidence of MACEs (OR 0.42, 95% CI 0.24-0.72, p=0.002) and a lower survival rate (OR 0.32, CI95%=0.12-0.90, p=0.03) than patients who had a decrease in PDW9.9%. In the Kaplan‒Meier analysis using log-rank test, patients who had a decrease in PDW<9.9% had an increased risk for MACEs (p=0.002) and lethal outcomes (p=0.002). However, a decrease in MPV or PLC-R did not have prognostic value. A decrease in PDW<9.9% measured 24 hours after clopidogrel treatment in NSTEMI patients has good prognostic value for determining the short-term risks of MACEs, possibly providing a better risk stratification of those patients.

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Prognostic value of a level of decrease in mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR) for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: an observational study

Published

2023-05-19

How to Cite

1.
Bećirović E, Ljuca K, Bećirović M, Ljuca N, Bajrić M, Brkić A, Ljuca F. Prognostic value of a level of decrease in mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR) for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: an observational study. Biomol Biomed [Internet]. 2023May19 [cited 2023May30];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/9178

Issue

Section

Translational and Clinical Research