Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study

Authors

  • Emir Bećirović Internal Medicine Clinic, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina https://orcid.org/0000-0002-4134-987X
  • Kenana Ljuca School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina; Health Center of Sarajevo Canton, Sarajevo, Bosnia and Herzegovina https://orcid.org/0009-0004-9478-3284
  • Minela Bećirović Internal Medicine Clinic, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina https://orcid.org/0009-0007-4391-5226
  • Nadina Ljuca School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina
  • Mugdim Bajrić Department of Cardiovascular Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina
  • Ammar Brkić Internal Medicine Clinic, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina https://orcid.org/0000-0002-5436-3670
  • Farid Ljuca Department of Physiology, School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina https://orcid.org/0000-0003-1143-1941

DOI:

https://doi.org/10.17305/bb.2023.9178

Keywords:

Mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio (P-LCR), major adverse cardiovascular events (MACE), myocardial infarction without ST-segment elevation

Abstract

The current study aimed to explore whether the level of decrease in platelet distribution width (PDW), platelet-large cell ratio (P-LCR), and mean platelet volume (MPV) has prognostic value for major adverse cardiovascular events (MACEs) in acute myocardial infarction without ST-segment elevation (NSTEMI) treated with clopidogrel. In this prospective observational cohort study, PDW, P-LCR, and MPV were determined on admission at the hospital and 24 h after clopidogrel treatment in 170 non-STEMI patients. MACEs were assessed over a one-year follow-up period. Using the Cox regression test, a decrease in PDW showed a significant association with the incidence of MACEs (odds ratio [OR] 0.82, 95% confidence interval [CI] 0.66–0.99, p = 0.049) and overall survival rate (OR 0.95, 95% CI = 0.91–0.99, p = 0.016). Patients with a decrease in PDW<9.9% had a higher incidence of MACEs (OR 0.42, 95% CI = 0.24–0.72, p = 0.002) and a lower survival rate (OR 0.32, 95% CI = 0.12–0.90, p = 0.03) than patients who had a decrease in PDW < 9.9%. In the Kaplan–Meier analysis using log-rank test, patients who had a decrease in PDW < 9.9% had an increased risk for MACEs (p = 0.002) and lethal outcomes (p = 0.002). However, a decrease in MPV or P-LCR did not have prognostic value. A decrease in PDW < 9.9% measured 24 h after clopidogrel treatment in NSTEMI patients has good prognostic value for determining the short-term risks of MACEs, possibly providing a better risk stratification of those patients.

Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study

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Published

04-09-2023

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Translational and Clinical Research

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How to Cite

1.
Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study. Biomol Biomed [Internet]. 2023 Sep. 4 [cited 2024 Feb. 23];23(5):866–872. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/9178