Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study

Authors

  • Hamda A. Al-Naemi Laboratory Animal Research Centre, Qatar University, Doha, Qatar; Department of Biological and Environmental Sciences, Qatar University, Doha, Qatar
  • Reem Moath Alasmar Laboratory Animal Research Centre, Qatar University, Doha, Qatar
  • Kaltham Al-Ghanim Social and Economic Survey Research Institute (SESRI), Qatar University, Doha, Qatar

DOI:

https://doi.org/10.17305/bb.2023.9239

Keywords:

Ethanolic plant extract, acute inflammation, α-carrageenan, paw edema

Abstract

Teucrium polium (germander, Lamiaceae) is a local plant in Qatar that has been used in folk medicine to treat numerous illnesses. It is known for its antioxidant, analgesic, anticancer, and antibacterial activities. This study aimed to evaluate the anti-inflammatory activity of Teucrium polium (TP) extract by α-carrageen-induced paw edema in adult Sprague Dawley rats. The animals were randomly grouped into control, acute inflammation, and plant extract groups. Acute inflammation was induced by a sub-plantar injection of 100 µL of 1% α-carrageenan into the rat’s right hind paw. Three different doses of the ethanolic extract of TP were tested at different time periods (1, 3, and 5 hours). All doses of the TP ethanolic extract showed significant inhibition of α-carrageenan-induced rat paw edema in a dose-dependent manner in both early and late phases of edema formation. The size of the α-carrageen induced paw edema was significantly reduced one, three, and five hours after TP extract injection compared to the acute inflammation group. This inhibition was accompanied by high expression of interleukin 10 (IL-10) and low expression of monocyte chemoattractant protein 1 (MCP-1), IL-1β and tumor necrosis factor alpha (TNF-α). The results indicated that the ethanolic extracts of TP possess significant anti-inflammatory and potential pharmaceutical properties.

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Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study

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Published

03-01-2024

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Section

Molecular Biology

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How to Cite

1.
Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study. Biomol Biomed [Internet]. 2024 Jan. 3 [cited 2024 Apr. 21];24(1):82–88. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/9239