Beyond hot flashes: Exploring the role of estrogen therapy in postmenopausal women for myocardial infarction prevention and recovery


  • Akash Choradia Kist Medical College, Kathmandu, Nepal
  • Karoona Bai Dow Medical College, Karachi, Pakistan
  • Suha Soni University of Texas Health Science Center School of Public Health, Texas, USA
  • Nhan Nguyen University of Debrecen, Debrecen, Hungary
  • Shikha Adhikari University College of Medical Sciences, New Delhi, India
  • Dalween Kaur Rahul Malaysian Medical Association, Malaysia
  • Rahul Gupta Independent Researcher, Khartoum, Sudan



Estrogen therapy, postmenopausal women, myocardial infarction prevention, cardiovascular health, hormone replacement therapy (HRT).


Myocardial infarction (MI) commonly known as "heart attack" results from the blockage of blood flow to the heart. Postmenopausal women face an elevated risk of MI due to declining estrogen levels, a hormone pivotal in maintaining cardiovascular health. It promotes vasodilation, reduces inflammation, and improves lipid profiles. While estrogen therapy shows promise in mitigating MI risk for postmenopausal women, its efficacy in prevention and recovery remains a subject of debate. This review provides a critical assessment of existing evidence on estrogen therapy's cardioprotective effects for postmenopausal women. It delves into estrogen's role in vascular function enhancement, inflammation reduction, and lipid metabolism modulation. Additionally, it addresses the various forms of estrogen therapy, administration methods, dosage considerations, safety implications, and associated risks. The review highlights the existing controversies and knowledge gaps related to estrogen therapy for MI prevention. It underscores the urgency for in-depth research to decipher the nexus between estrogen therapy and MI risk, especially concerning primary prevention and specific postmenopausal subgroups. Future studies should investigate optimal formulations, doses, and administration routes of estrogen therapy as well as assess treatment timing and duration. Comparative studies and long-term follow-up are necessary to inform clinical decision-making and improve patient care. Addressing these research gaps will empower clinicians to make more judicious choices about estrogen therapy for MI prevention and recovery in postmenopausal women, aiming for enhanced patient outcomes.




Download data is not yet available.



How to Cite

Choradia A, Bai K, Soni S, Nguyen N, Adhikari S, Kaur Rahul D, Gupta R. Beyond hot flashes: Exploring the role of estrogen therapy in postmenopausal women for myocardial infarction prevention and recovery. Biomol Biomed [Internet]. 2023Aug.28 [cited 2023Sep.28];. Available from: