The mechanism of high mobility group box-1 protein and its bidirectional regulation in tumors
Keywords:HMGB1, tumor, autophagy, Immunity, drug resistance
High mobility group protein box-1 (HMGB1) is a nonhistone chromatin-related protein widely found in eukaryotic cells. It is involved in the transcription, replication and repair of DNA to maintain nuclear homeostasis. It participates in cell growth, differentiation and signal transduction. Recent studies showed that HMGB1 has a bidirectional regulatory effect on tumors by regulating TLR4/MYD88/NF-κB and RAGE/AMPK/mTOR signaling pathways. On one hand, it is highly expressed in a variety of tumors, promoting tumor proliferation and invasion, whilst on the other hand, it induces autophagy and apoptosis of tumor cells and stimulates tumor-infiltrating lymphocytes to produce anti-tumor immune response. At present, HMGB1 could be used as a target to regulate the drug-resistance and prognostication in cancer. Clinical applications of HMGB1 in cancer need further in-depth studies.
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Copyright (c) 2023 Zhongjia Tian, Lin Zhu, Yutong Xie, Huan Hu, Qunli Ren, Jianguo Liu, Qian Wang
This work is licensed under a Creative Commons Attribution 4.0 International License.