Action of Propranolol in the Reaction of Smooth Musculature of Tracheal Rings Induced with Acetylcholine, Histamine, Serotonin (5-Ht) And Prostaglandin (Pgf2-alfa) in vitro and in vivo
Keywords: Trachea, ACh, propranolol, histamine, 5-HT and PGF2-alfa
AbstractActions of acetylcholine (ACh), histamines, serotonins (5-HT) and prostaglandins (PGF2-alfa) in concentrations of 10-4, 10-3, 10-1 and 10-1 mol/dm3 were analyzed in vitro conditions in isolated specimens of tracheas of 24 pigs, 7 guinea pigs, and dead persons for different reasons (8), in the presence and without presence of propranolol. Whilst, research regarding actions of aerosolized histamines (10 mg, 1%, 2 min), in the presence and without the presence of aerosolized propranolol (20 mg, 2%, 2 min) was done in vivo in 6 healthy persons. Study results show that propranolol does not emphasize contraction of the airways smooth musculature as induced by ACh, histamine, 5-HT and PGF2-alfa in vitro conditions (p>0,1). Also, in vivo we found a non-significance of tracheal smooth musculature constriction (p>0,1).
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Islami H, Bexheti S, Ahmetaj H, Šukalo A, Manxhuka S, Nuraj B, Kamberi X, Krasniqi S, Qorraj H, Kastrati B, Disha M. Action of Propranolol in the Reaction of Smooth Musculature of Tracheal Rings Induced with Acetylcholine, Histamine, Serotonin (5-Ht) And Prostaglandin (Pgf2-alfa) in vitro and in vivo. Bosn J of Basic Med Sci [Internet]. 2009May20 [cited 2019Sep.18];9(2):142-7. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/2834
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