Action of Propranolol in the Reaction of Smooth Musculature of Tracheal Rings Induced with Acetylcholine, Histamine, Serotonin (5-Ht) And Prostaglandin (Pgf2-alfa)  in vitro and in vivo

Hilmi Islami; Sadi Bexheti; Halil Ahmetaj; Aziz Šukalo; Suzana Manxhuka; Bajram Nuraj; Xhevat Kamberi; Shaip Krasniqi; Hasime Qorraj; Bashkim Kastrati; Mentor Disha

doi:10.17305/bjbms.2009.2834

Authors

Hilmi Islami Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
Sadi Bexheti Department of Anatomy, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
Halil Ahmetaj Department of Pathophysiology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
Aziz Šukalo Drugs factory-Bosnalijek -Sarajevo, Bosnalijek dd
Suzana Manxhuka Department of Pathology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
Bajram Nuraj Department of Anatomy, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
Xhevat Kamberi Department of Pathology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
Shaip Krasniqi Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
Hasime Qorraj Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
Bashkim Kastrati Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
Mentor Disha Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000

DOI:

https://doi.org/10.17305/bjbms.2009.2834

Keywords:

Trachea, ACh, propranolol, histamine, 5-HT and PGF2-alfa

Abstract

Actions of acetylcholine (ACh), histamines, serotonins (5-HT) and prostaglandins (PGF2-alfa) in concentrations of 10-4, 10-3, 10-1 and 10-1 mol/dm³ were analyzed in vitro conditions in isolated specimens of tracheas of 24 pigs, 7 guinea pigs, and dead persons for different reasons (8), in the presence and without presence of propranolol. Whilst, research regarding actions of aerosolized histamines (10 mg, 1%, 2 min), in the presence and without the presence of aerosolized propranolol (20 mg, 2%, 2 min) was done in vivo in 6 healthy persons. Study results show that propranolol does not emphasize contraction of the airways smooth musculature as induced by ACh, histamine, 5-HT and PGF2-alfa in vitro conditions (p>0,1). Also, in vivo we found a non-significance of tracheal smooth musculature constriction (p>0,1).