Action of Propranolol in the Reaction of Smooth Musculature of Tracheal Rings Induced with Acetylcholine, Histamine, Serotonin (5-Ht) And Prostaglandin (Pgf2-alfa) in vitro and in vivo

Authors

  • Hilmi Islami Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Sadi Bexheti Department of Anatomy, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Halil Ahmetaj Department of Pathophysiology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Aziz Šukalo Drugs factory-Bosnalijek -Sarajevo, Bosnalijek dd
  • Suzana Manxhuka Department of Pathology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Bajram Nuraj Department of Anatomy, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Xhevat Kamberi Department of Pathology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Shaip Krasniqi Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Hasime Qorraj Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Bashkim Kastrati Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Mentor Disha Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000

DOI:

https://doi.org/10.17305/bjbms.2009.2834

Keywords:

Trachea, ACh, propranolol, histamine, 5-HT and PGF2-alfa

Abstract

Actions of acetylcholine (ACh), histamines, serotonins (5-HT) and prostaglandins (PGF2-alfa) in concentrations of 10-4, 10-3, 10-1 and 10-1 mol/dm3 were analyzed in vitro conditions in isolated specimens of tracheas of 24 pigs, 7 guinea pigs, and dead persons for different reasons (8), in the presence and without presence of propranolol. Whilst, research regarding actions of aerosolized histamines (10 mg, 1%, 2 min), in the presence and without the presence of aerosolized propranolol (20 mg, 2%, 2 min) was done in vivo in 6 healthy persons. Study results show that propranolol does not emphasize contraction of the airways smooth musculature as induced by ACh, histamine, 5-HT and PGF2-alfa in vitro conditions (p>0,1). Also, in vivo we found a non-significance of tracheal smooth musculature constriction (p>0,1).

Downloads

Download data is not yet available.
Action of Propranolol in the Reaction of Smooth Musculature of Tracheal Rings Induced with Acetylcholine, Histamine, Serotonin (5-Ht) And Prostaglandin (Pgf2-alfa)  in vitro and in vivo

Downloads

Published

20-05-2009

Issue

Section

Pharmacology

Categories

How to Cite

1.
Action of Propranolol in the Reaction of Smooth Musculature of Tracheal Rings Induced with Acetylcholine, Histamine, Serotonin (5-Ht) And Prostaglandin (Pgf2-alfa) in vitro and in vivo. Biomol Biomed [Internet]. 2009 May 20 [cited 2024 Feb. 20];9(2):142-7. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2834