Action of Propranolol in the Reaction of Smooth Musculature of Tracheal Rings Induced with Acetylcholine, Histamine, Serotonin (5-Ht) And Prostaglandin (Pgf2-alfa) in vitro and in vivo

  • Hilmi Islami Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Sadi Bexheti Department of Anatomy, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Halil Ahmetaj Department of Pathophysiology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Aziz Šukalo Drugs factory-Bosnalijek -Sarajevo, Bosnalijek dd
  • Suzana Manxhuka Department of Pathology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Bajram Nuraj Department of Anatomy, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Xhevat Kamberi Department of Pathology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Shaip Krasniqi Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Hasime Qorraj Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Bashkim Kastrati Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
  • Mentor Disha Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. 10000
Keywords: Trachea, ACh, propranolol, histamine, 5-HT and PGF2-alfa

Abstract

Actions of acetylcholine (ACh), histamines, serotonins (5-HT) and prostaglandins (PGF2-alfa) in concentrations of 10-4, 10-3, 10-1 and 10-1 mol/dm3 were analyzed in vitro conditions in isolated specimens of tracheas of 24 pigs, 7 guinea pigs, and dead persons for different reasons (8), in the presence and without presence of propranolol. Whilst, research regarding actions of aerosolized histamines (10 mg, 1%, 2 min), in the presence and without the presence of aerosolized propranolol (20 mg, 2%, 2 min) was done in vivo in 6 healthy persons. Study results show that propranolol does not emphasize contraction of the airways smooth musculature as induced by ACh, histamine, 5-HT and PGF2-alfa in vitro conditions (p>0,1). Also, in vivo we found a non-significance of tracheal smooth musculature constriction (p>0,1).

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Published
2009-05-20
How to Cite
1.
Islami H, Bexheti S, Ahmetaj H, Šukalo A, Manxhuka S, Nuraj B, Kamberi X, Krasniqi S, Qorraj H, Kastrati B, Disha M. Action of Propranolol in the Reaction of Smooth Musculature of Tracheal Rings Induced with Acetylcholine, Histamine, Serotonin (5-Ht) And Prostaglandin (Pgf2-alfa) in vitro and in vivo. Bosn J of Basic Med Sci [Internet]. 2009May20 [cited 2019May22];9(2):142-7. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2834
Section
Pharmacology

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