ß-endorphins as Possible Markers for Therapeutic Drug Monitoring

  • Radivoj Jadrić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Emina Kiseljaković Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Sabaheta Hasić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Mira Winterhalter-Jadrić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Keywords: amitriptyline, trazodone, β-endorphins, rat, brain

Abstract

This study was performed in order to investigate possible role of brain beta-endorphins as markers of antidepressive drugs therapy monitoring. Experiment was done using amitriptyline and trazodone as antidepressants. For quantification of brain beta-endorphins we used RIA technique. Our results showed significant decrease of brain beta-endorphins concentration in drug-pretreated animals, vs. those in of control group treated with 0,95% NaCl. The lower values were obtained in trazodone pre-treated animals. This study shows that use of psychoactive drugs have influence on brain beta-endorphins concentration. beta-endorphins could be of great importance, used as markers for evaluation of patient treatment.

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Published
2007-02-20
How to Cite
1.
Jadrić R, Kiseljaković E, Hasić S, Winterhalter-Jadrić M. ß-endorphins as Possible Markers for Therapeutic Drug Monitoring. Bosn J of Basic Med Sci [Internet]. 2007Feb.20 [cited 2019Aug.25];7(1):11-5. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/3081
Section
Biochemistry

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