ß-endorphins as Possible Markers for Therapeutic Drug Monitoring

Radivoj Jadrić; Emina Kiseljaković; Sabaheta Hasić; Mira Winterhalter-Jadrić

doi:10.17305/bjbms.2007.3081

Authors

Radivoj Jadrić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Emina Kiseljaković Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Sabaheta Hasić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Mira Winterhalter-Jadrić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo

DOI:

https://doi.org/10.17305/bjbms.2007.3081

Keywords:

amitriptyline, trazodone, β-endorphins, rat, brain

Abstract

This study was performed in order to investigate possible role of brain beta-endorphins as markers of antidepressive drugs therapy monitoring. Experiment was done using amitriptyline and trazodone as antidepressants. For quantification of brain beta-endorphins we used RIA technique. Our results showed significant decrease of brain beta-endorphins concentration in drug-pretreated animals, vs. those in of control group treated with 0,95% NaCl. The lower values were obtained in trazodone pre-treated animals. This study shows that use of psychoactive drugs have influence on brain beta-endorphins concentration. beta-endorphins could be of great importance, used as markers for evaluation of patient treatment.