Serum KL-6 and the mortality of patients with connective tissue disease-associated interstitial lung disease: A meta-analysis

Authors

  • Mei Hong Department of Dermatology, The People’s Hospital of Wuhai, Wuhai, China
  • Xue Yin Department of Pulmonary and Critical Care Medicine, The People’s Hospital of Wuhai, Wuhai, China
  • Wenmei Yan Department of Pulmonary and Critical Care Medicine, The People’s Hospital of Wuhai, Wuhai, China
  • Wei Guo Department of Dermatology, The People’s Hospital of Wuhai, Wuhai, China
  • Hongmei Liu Department of Pulmonary and Critical Care Medicine, The People’s Hospital of Wuhai, Wuhai, China
  • Haisheng Yang Department of Pulmonary and Critical Care Medicine, The People’s Hospital of Wuhai, Wuhai, China

DOI:

https://doi.org/10.17305/bb.2024.10368

Keywords:

Interstitial lung disease (ILD), connective tissue disease (CTD), Krebs von den Lungen-6 (KL-6), mortality, meta-analysis

Abstract

Connective tissue disease-associated interstitial lung disease (CTD-ILD) is an important underlying cause of morbidity and mortality in patients with CTD. Serum Krebs von den Lungen-6 (KL-6) is an immune factor which has been related to the severity of ILD. This systematic review and meta-analysis aimed to evaluate the association between serum KL-6 and mortality of patients with CTD-ILD. Longitudinal studies relevant to the aim of the meta-analysis were retrieved by search of electronic databases including PubMed, Web of Science, and Embase. A random-effects model was used to combine the data by incorporating the influence of between-study heterogeneity. Fifteen cohorts involving 1737 patients with CTD-ILD were included. During a mean follow-up of 35.3 months, 430 (24.8%) patients died. Compared to those with a lower KL-6 at admission, patients with a higher KL-6 were associated with a higher mortality risk during follow-up (risk ratio: 2.18, 95% confidence interval: 1.66 to 2.87, P < 0.001; I2 = 20%). Subgroup analysis showed a significant association in studies from Asian countries, but not in those from non-Asian countries; in studies with cutoff of KL-6 derived in receiver operating characteristic (ROC) curve analysis, but not in those derived from other methods; in studies with multivariate analysis, but not in those with univariate analysis (P for subgroup difference all < 0.05). The association was not significantly affected by different CTDs or methods for measuring serum KL-6. In conclusion, a high serum KL-6 may be a risk factor of increased mortality in patients with CTD-ILD.

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Serum KL-6 and the mortality of patients with connective tissue disease-associated interstitial lung disease: A meta-analysis

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Published

06-09-2024

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Section

Systematic review/Meta analysis

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How to Cite

1.
Serum KL-6 and the mortality of patients with connective tissue disease-associated interstitial lung disease: A meta-analysis. Biomol Biomed [Internet]. 2024 Sep. 6 [cited 2024 Oct. 5];24(5):1105–1116. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/10368