Polymorphism in Methylentetrahydrofolate Reductase Gene: Important Role in Diseases

  • Emina Kiseljaković Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Radivoj Jadrić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Sabaheta Hasić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Faruk Skenderi Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Halima Resić Center for Haemodialysis, University of Sarajevo Clinics Centre
  • Mira Winterhalter-Jadrić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Keywords: MTHFR, Homocysteine, polymorphism diseases

Abstract

It has been recognized that some people have a genetic variant which leads to elevated levels of homocysteine and impairs ability to process folate. This condition was recognized as independent risk factor of coronary heart disease. Recently, connection between this termolabile mutation of the methylenetetrahydrofolate reductase and numerous conditions and diseases has been established. Aim of this review is to draw attention to this interesting area in medicine. Additionally, well defined study about presence and frequency of gene polymorphism in our region will provide proper diagnosis and achieve possible delay of development of diseases with vitamin supplementation.

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Published
2008-05-20
How to Cite
1.
Kiseljaković E, Jadrić R, Hasić S, Skenderi F, Resić H, Winterhalter-Jadrić M. Polymorphism in Methylentetrahydrofolate Reductase Gene: Important Role in Diseases. Bosn J of Basic Med Sci [Internet]. 2008May20 [cited 2019Mar.25];8(2):165-9. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2975
Section
Reviews

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