The Dry Plant Extract of Common Bean Seed (Phaseoli Vulgari Pericarpium) does not Have an Affect on Postprandial Glycemia in Healthy Human Subject

  • Aleksandra Cerović Department of Bromatology, Faculty of Pharmacy, University of Belgrade
  • Ivanka Miletić Department of Bromatology, Faculty of Pharmacy, University of Belgrade
  • Aleksandra Konić-Ristić Department of Bromatology, Faculty of Pharmacy, University of Belgrade
  • Ivana Baralić Department of Bromatology, Faculty of Pharmacy, University of Belgrade
  • Brižita Djordjević Department of Bromatology, Faculty of Pharmacy, University of Belgrade
  • Ivana Djuričić Department of Bromatology, Faculty of Pharmacy, University of Belgrade
  • Miodrag Radusinović Department of Bromatology, Faculty of Pharmacy, University of Belgrade
Keywords: alternative medicine, Phaseoli vulgari pericarpium, postprandial, glucose

Abstract

The aim of present study was to assess the effects and safety of a dry Phaseoli vulgari pericarpium (PVP) extract on postprandial glycemia in healthy participants. A randomized crossover experiment where participants received either PVP extract or placebo. Chemical compounds in dry extract were assessed by established methods. Eighteen healthy participants (9 male and 9 female) aged 29+/-4,8 years, body mass index (BMI) 23+/-3,7 kg/m(2) were recruited among students and staff at the Faculty of Pharmacy, University of Belgrade. All participants were able to follow the study protocol without difficulty. The participants received either PVP extract or placebo 30 minutes before a 50g oral glucose tolerance test (OGTT). The protocol followed the guidelines for the OGTT with blood samples drawn at 0, 15, 30, 60, 90 and 120 min. This study demonstrated that there was no significantly effect of the PVP extract on incremental blood glucose (IBG) and their areas under the curve (AUC) neither male nor female participants. However, IBG together with AUC changes were significantly lower in male compared with female participants in treated and untreated groups. The presence of chrome, soluble fiber, vitamin C, protein, glucose and lectins were also quantified. The applied amount of PVP extract was unable to produce the postprandial hypoglycemia. We assumed that amounts of chrome, soluble fiber, vitamin C which have beneficial effects on diabetes treatment were sufficient to produce hypoglycemia.

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The Dry Plant Extract of Common Bean Seed (Phaseoli Vulgari Pericarpium) does not Have an Affect on Postprandial Glycemia in Healthy Human Subject
Published
2006-08-20
How to Cite
1.
Cerović A, Miletić I, Konić-Ristić A, Baralić I, Djordjević B, Djuričić I, Radusinović M. The Dry Plant Extract of Common Bean Seed (Phaseoli Vulgari Pericarpium) does not Have an Affect on Postprandial Glycemia in Healthy Human Subject. Bosn J of Basic Med Sci [Internet]. 2006Aug.20 [cited 2021Oct.20];6(3):28-3. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3140
Section
Pharmacology