Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro

  • Aziz Šukalo Bosnalijek-Pharmaceutical Company - Sarajevo
  • Hilmi Islami Institute for Pharmacology, Faculty of Medicine, University of Pristhina
  • Ragib Shabani Institute for Pathology, Faculty of Medicine, University of Prishtina
  • Hilmi Dauti Institute for Anatomy, Faculty of Medicine, University of Prishtina
  • Skender Kutllovci Bosnalijek-Pharmaceutical Company - Sarajevo
  • Bashkim Kastrati Institute for Pharmacology, Faculty of Medicine, University of Prishtina
Keywords: cholinergic, adrenergic, histaminergic and serotonergic receptors, human trachea

Abstract

Research was done on pharmacological-physiological development of the bronchial receptor system on the smooth muscles of trachea in the newborn children, alive-born and stillborn children. Monitored was the response on: acetylcholine, dopamine, histamine and serotonin in different molar concentrations 10(-4), 10(-3), 10(-2), 10 mol/dm(-3), micromol/dm(-3)). Research was done on tonus of tracheal smooth muscles of 23 tracheal preparations taken by autopsy after death from different factors. Based on pharmacological-physiological research on the preparations of human isolated trachea it was find out that: acetylcholine stimulation effect is significant (p>0,01) in 38-41 weeks of pregnancy comparing with that in 30-37 weeks of pregnancy (p>0,01), while dopamine stimulation effect is significant (p>0,05) in 30-37 pregnancy weeks comparing with the effect of acetylcholine and dopamine on the still-born infants of the same pregnancy period (p<0,01). Histaminic receptors were developed during intrauterine life after 38 weeks of pregnancy (p>0,025). Serotonin has caused contraction of the bronchial smooth muscles after 30 pregnancy weeks, but response was not significant (p<0,01). This suggests that cholinergic and adrenergic system of the airways in alive newborn infants develops in parallel intrauterine, contrary to other systems which develop in certain extrauterine life phases.

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Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro
Published
2006-08-20
How to Cite
1.
Šukalo A, Islami H, Shabani R, Dauti H, Kutllovci S, Kastrati B. Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro. Bosn J of Basic Med Sci [Internet]. 2006Aug.20 [cited 2021Jun.23];6(3):73-7. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3149
Section
Short Communication