Antihypertensive treatment in patients with end-stage renal disease

  • Mensura Aščerić Department of Pharmacology and Toxicology, University of Tuzla, Medical Faculty
  • Nedžad Mulabegović Department of Pharmacology and Toxicology, University of Sarajevo, Medical Faculty
  • Sabina Nuhbegović Department of Physiology, University of Tuzla, Medical Faculty
  • Alma Nadarević Polyclinic for Pulmonary Diseases and TBC of Clinic of Health
  • Muamera Mujčinagić-Vrabac Family Practice of Clinic of Health
Keywords: Hypertension, haemodialysis, ultra filtration, trandolapril

Abstract

Arterial hypertension is a common finding in patients with end stage renal disease (80% patients are hypertensive). Cardiovascular diseases are the main cause of death in haemodialysis. The present study was performed to asses' successful treatment in hypertensive chronic haemodialysis patients by ultra filtration only and ultra filtration combined with medics. We studied 80 hypertensive adult patients who had been on regular haemodialysis treatment for at least 12 months (average duration of 41 months). All subjects were divided in two different antihypertensive treatment groups including 40 subjects each. The first group of patients were treated with trandolapril and ultra filtration, and the second group of patients were only treated with ultra filtration (control group). Blood pressure measurements before and after HD sessions were performed for each patient. Blood pressure control was defined using World Health Organizationcriteria 140/90 mm Hg. Average systolic blood pressure levels, after haemodialysis, were in the first group of patients 146.33 +/- 9.7 mm Hg, and in the control group 157,86 +/- 10.33 mm Hg. Average diastolic blood pressure was 87.83 +/- 8.11 mm Hg in the first group of patients and, in the control group it was 91.03 +/- 10.67 mm Hg. There were significant differences between systolic blood pressure level in the first group of patients and the control group of patients as well as in diastolic blood pressure (p < 0.05). We conclude that an antihypertensive therapy by trandolapril is more effective than ultra filtration alone in hypertensive patients on chronic haemodialysis.

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Published
2005-11-20
How to Cite
1.
Aščerić M, Mulabegović N, Nuhbegović S, Nadarević A, Mujčinagić-Vrabac M. Antihypertensive treatment in patients with end-stage renal disease. Bosn J of Basic Med Sci [Internet]. 2005Nov.20 [cited 2019Mar.24];5(4):22-5. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3225
Section
Translational and Clinical Research