The Bcl-2 protein: a prognostic indicator strongly related to ER and PR in breast cancer

  • Nurija Bilalović Department of Pathology, School of Medicine, University of Sarajevo
  • Semir Vranić School of Medicine, University of Sarajevo
  • Senad Hasanagić School of Medicine, University of Sarajevo
  • Hiba Basić Department of Oncology, University Clinical Center Sarajevo
  • Aida Tatarević Department of Oncology, University Clinical Center Sarajevo
  • Semir Bešlija Department of Oncology, University Clinical Center Sarajevo
  • Ivan Selak Department of Pathology, School of Medicine, University of Sarajevo
Keywords: bcl-2, ER, PR, breast cancer, estrogen, progesterone

Abstract

Bcl-2, the protein product of the Bcl-2 gene, is a member of the Bcl-2 family of proteins that play a crucial role in a complex mechanism of apoptosis. It was recently proposed that bcl-2 could inhibit cancer progression. In this study, we evaluated the expression patterns of Bcl-2, estrogen receptors (ER), progesterone receptors (PR) in 71 primary invasive breast carcinomas and their association with other clinicopathological parameters. Samples from 71 patients with invasive breast cancer with follow-up ranging from 4-103 months (median 57 months) were included in the study. Forty-six patients (66%) obtained a complete response, while 5 (9%) were considered non-responders during the follow up period of 103 months. Eighteen (25%) patients died, 15 (21%) from primary disease and 3 (4%) from other disease. In unvaried analysis, tumor size (<2 cm), lymph node (<4 lymph nodes), hormonal status and Bcl-2 expression are correlated with longer overall (OS) and relapse-free survival (RFS). Patients with 4 or more positive axillary lymph nodes had significantly shorter OS (p=0.01) and RFS (p=0.009). Higher expression of Bcl-2 was associated with longer OS (p=0.02) and RFS (p=0.03), and this result were independent of axillary lymph nodes and tumor size in Cox multivariate analysis.

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The Bcl-2 protein: a prognostic indicator strongly related to ER and PR in breast cancer
Published
2004-11-20
How to Cite
1.
Bilalović N, Vranić S, Hasanagić S, Basić H, Tatarević A, Bešlija S, Selak I. The Bcl-2 protein: a prognostic indicator strongly related to ER and PR in breast cancer. Bosn J of Basic Med Sci [Internet]. 2004Nov.20 [cited 2020Oct.1];4(4):5-12. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3352
Section
Pathology