Development of the rat telencephalon-volumetric analysis

  • Selma Aličelebić Institute of Histology and Embryology School of Medicine, University of Sarajevo
  • Đurđica Grbeša Department of Histology and Embryology, School of Medicine, University of Zagreb
Keywords: rat telencephalon, development, stereology

Abstract

With regard to intensive morphometric changes, morphometry as a method is mainly used for histogenetic studies of brain development in normal and experimental conditions. The aim of our study was to quantitatively analyse morphological parameters of the rat telencephalon during embryonic development. The investigation was carried out on semithin serial sections of rat brain from embryonic days 12 to 15. The volume densities (VV) of the lateral ventricles, the telencephalic neuroepithelium and the surrounding mesenchyme have been analysed stereologically and compared in examined embryonic stages. The neuroepithelial volume density was the smallest (28%) at E13 and the biggest (44%) at E15 (p<0.0005). The mesenchymal volume density was the smallest (32%) at E13 and the biggest (48%) at E14 (p<0.0005). The volume density of lateral ventricles was the biggest (40%) at E13 and the smallest (14%) at E15 (p<0.0005). Neurostereological methods have been making a very valuable contribution to neuroscience over recent years. We have used unbiased stereological counting methods to obtain objective quantitative parameters which show relations between some parts of rat embryonic telencephalon examined during its normal development.

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Development of the rat telencephalon-volumetric analysis
Published
2004-08-20
How to Cite
1.
Aličelebić S, Grbeša Đurđica. Development of the rat telencephalon-volumetric analysis. Bosn J of Basic Med Sci [Internet]. 2004Aug.20 [cited 2020Oct.28];4(3):11-4. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3375
Section
Pathology