Mathematical methods for quantification and comparison of dissolution testing data

Authors

  • Edina Vranić Department of Pharmaceutical Technology
  • Aida Mehmedagić Department of Pharmacokinetics, University of Sarajevo, Faculty of Pharmacy
  • Sabira Hadžović Department of Pharmaceutical Technology

DOI:

https://doi.org/10.17305/bjbms.2002.3581

Keywords:

dissolution testing, difference factor, similarity factor, quantification, comparison, solid dosage forms

Abstract

In recent years, drug release/dissolution from solid dosage forms has been the subject of intense and profitable scientific developments. Whenever a new solid dosage form is developed or produced, it is necessary to ensure that drug dissolutionoccurs in an appropriate manner. The pharmaceutical industry and the registration authorities do focus, nowadays, on drug dissolution studies. The quantitative analysis of the values obtained in dissolution/release tests is easier when mathematicalformulas that express the dissolution results as a function of some of the dosage forms characteristics are used. This work discusses the analysis of data obtained for dissolution profiles under different media pH conditions using mathematical methodsof analysis described by Moore and Flanner. These authors have described difference factor (f1) and similarity factor (f2), which can be used to characterise drug dissolution/release profiles. In this work we have used these formulas for evaluation of dissolution profiles of the conventional tablets in different pH of dissolution medium (range of physiological variations).

Downloads

Download data is not yet available.
Mathematical methods for quantification and comparison of dissolution testing data

Published

20-02-2002

Issue

Section

Reviews

Categories

How to Cite

1.
Mathematical methods for quantification and comparison of dissolution testing data. Biomol Biomed [Internet]. 2002 Feb. 20 [cited 2024 May 18];2(1-2):49-52. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3581