The new trends in theophylline therapy

Authors

  • Aida Mehmedagić Department of Pharmacokinetics,
  • Edina Vranić Department of Pharmaceutical Technology, University of Sarajevo, Faculty of Pharmacy
  • Sabira Hadžović Department of Pharmaceutical Technology, University of Sarajevo, Faculty of Pharmacy
  • Milena Pokrajac Department of Pharmacokinetics
  • Jela Milić Department of Pharmaceutical Technology, University of Belgrade, Faculty of Pharmacy
  • Bakir Mehić Clinic for lung diseases and tuberculosis “Podhrastovi” Clinical Center of the University of Sarajevo
  • Hasan Žutić Clinic for lung diseases and tuberculosis “Podhrastovi” Clinical Center of the University of Sarajevo
  • Abdulah Konjicija Clinic for lung diseases and tuberculosis “Podhrastovi” Clinical Center of the University of Sarajevo

DOI:

https://doi.org/10.17305/bjbms.2002.3584

Keywords:

theophylline, sustained-release, pellets, asthma, theophylline serum concentrations, lung function parameters, once-daily evening administration

Abstract

Sustained-release theophylline pellets formulation for once-daily evening administration significantly improved patients compliance and adjusted serum levels profile of the drug. The patients conversion from i.v. to p.o. therapy is one of the most critical steps in the treatment of asthma according to its chronopathophysiological character. In our study we have examined safety and efficiency of this conversion in twelve hospitalised asthmatic patients who were given the new sustained-release theophylline pellets formulation for once-daily evening administration. The lung function parameters (FEV1, VC, RV, and Rt) and serum theophylline concentrations were monitored. So, the values obtained for the last day of i.v. therapy and the fifth day of p.o. therapy were compared. We found that 75% of the patients had no change or improved lung function on the conversion. Our results indicate that this conversion from i.v. to p.o. theophylline therapy is safe and could be efficacious. Also, the maximum theophylline serum levels could safely be predicted by measuring only one serum concentration in p.o. therapy with sustained-release theophylline pellets formulation for once-daily evening administration.

The new trends in theophylline therapy

Published

20-02-2002

Issue

Section

Short Communication

Categories

How to Cite

1.
The new trends in theophylline therapy. Biomol Biomed [Internet]. 2002 Feb. 20 [cited 2024 Mar. 1];2(1-2):62-5. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3584