The Effects of Combined SarCNU and Ganglioside Treatment of Growth of C6 Glioma Cell Cultures

Authors

  • Adlija Jevrić-Čaušević Faculty of Pharmaceutical Sciences, Sarajevo University of Sarajevo

DOI:

https://doi.org/10.17305/bjbms.1998.3608

Keywords:

C6 glioma, SarCNU, Ganglioside GMI, cytotoxicity, antiproliferative effects

Abstract

In vitro antiproliferative effects of SarCNU and GMI ganglioside were tested in different concentration ratios in C6 glioma cell culture. Based on MTT assay and a protein assay, cytotoxicity of each agent separately and the two agents combined was tested. When the cells were treated with different concentrations of ganglioside ranging from 10-’ to 10-2, the number of viable cells decreased highly on days two and seven, regardless of the concentration of the agent applied. SarCNU, as expected, has caused antiproliferative effects which highly correlated with the concentration of the agent tested. When the C6 glioma cell culture was treated with the two agents combined in the optimal concentration causing the above mentioned cytotoxicity, effects observed did not correlate with those observed for each agent alone, suggesting in this case the expression of highly neuroprotective effects of ganglioside GMI.

The Effects of Combined SarCNU and Ganglioside Treatment of Growth of C6 Glioma Cell Cultures

Published

20-02-1998

How to Cite

1.
The Effects of Combined SarCNU and Ganglioside Treatment of Growth of C6 Glioma Cell Cultures. Biomol Biomed [Internet]. 1998 Feb. 20 [cited 2024 Mar. 28];1(1):20-3. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3608