MPTP-induced mouse model of Parkinson’s disease: A promising direction of therapeutic strategies

  • Musa Mustapha Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti PutraMalaysia, Serdang, Selangor (Darul Ehsan), Malaysia; Department of Human Anatomy, Faculty of Basic Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria https://orcid.org/0000-0002-9280-8482
  • Che Norma Mat Taib Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti PutraMalaysia, Serdang, Selangor (Darul Ehsan), Malaysia https://orcid.org/0000-0002-4534-5614
Keywords: Parkinson's disease, MPTP, C57BL mouse, MPTP-induced PD mouse

Abstract

Among the popular animal models of Parkinson’s disease (PD) commonly used in research are those that employ neurotoxins, especially 1-methyl- 4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). This neurotoxin exerts it neurotoxicity by causing a barrage of insults, such as oxidative stress, mitochondrial apoptosis, inflammation, excitotoxicity, and formation of inclusion bodies acting singly and in concert, ultimately leading to dopaminergic neuronal damage in the substantia nigra pars compacta and striatum. The selective neurotoxicity induced by MPTP in the nigrostriatal dopaminergic neurons of the mouse brain has led to new perspectives on PD. For decades, the MPTP-induced mouse model of PD has been the gold standard in PD research even though it does not fully recapitulate PD symptomatology, but it does have the advantages of simplicity, practicability, affordability, and fewer ethical considerations and greater clinical correlation than those of other toxin models of PD. The model has rejuvenated PD research and opened new frontiers in the quest for more novel therapeutic and adjuvant agents for PD. Hence, this review summarizes the role of MPTP in producing Parkinson-like symptoms in mice and the experimental role of the MPTP-induced mouse model. We discussed recent developments of more promising PD therapeutics to enrich our existing knowledge about this neurotoxin using this model.

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Author Biography

Musa Mustapha, Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti PutraMalaysia, Serdang, Selangor (Darul Ehsan), Malaysia; Department of Human Anatomy, Faculty of Basic Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria

He is a lecturer in Department of Human Anatomy, Faculty of Basic Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria and PhD student in Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor (Darul Ehsan), Malaysia.

MPTP-induced mouse model of Parkinson’s disease: A promising direction of therapeutic strategies
Published
2020-12-14
How to Cite
1.
Mustapha M, Mat Taib CN. MPTP-induced mouse model of Parkinson’s disease: A promising direction of therapeutic strategies. Bosn J of Basic Med Sci [Internet]. 2020Dec.14 [cited 2021Apr.18];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/5181
Section
Reviews

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