Relationship between PD-L1 expression and prognostic factors in high-risk cutaneous squamous and basal cell carcinoma

Authors

  • Özden Yülek Department of Pathology, Siirt Research and Training Hospital, Siirt, Turkey https://orcid.org/0000-0001-7557-0268
  • Şebnem Batur Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey
  • Kerem Özcan Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA https://orcid.org/0000-0003-4267-4794
  • Cansu Yol Department of Pathology, Mehmet Akif Inan Training and Research Hospital, School of Medicine, University of Health Sciences, Sanliurfa, Turkey https://orcid.org/0000-0002-8151-2889
  • Övgü Aydın Ülgen Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey https://orcid.org/0000-0002-1773-8816

DOI:

https://doi.org/10.17305/bjbms.2022.7574

Keywords:

Cutaneous squamous cell carcinoma, basal cell carcinoma, PD-L1

Abstract

This study aimed to investigate the programmed cell death-ligand 1 (PD-L1) expression in cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) and its relationship with prognostic factors in tumors that are not in the head and neck region and are therefore relatively less exposed to the sun. This retrospective cross-sectional study included 25 invasive cSCC and 42 BCC cases with a diameter ≥ 2 cm located outside the head and neck region from 2010 to 2018. The biopsy samples were examined based on the membranous PD-L1 (22C3 clone) staining. Staining results were scored as follows: 0, no staining (negative); 1, < 10% PD-L1 positivity of tumor cells; and 2, ≥ 10% PD-L1 positivity of tumor cells. PD-L1 positivity was not seen in any BCC cases, whereas 11 (44%) of cSCC cases were PD-L1 positive. No significant relationship was observed between PD-L1 expression and prognostic parameters, including tumor diameter, tumor depth, and lymphovascular or perineural invasion in the cSCC group. PD-L1 expression was not associated with prognostic factors in the early stages of BCC and SCC located outside the head and neck region. Therefore, investigating the PD-L1 expression seems to be more relevant in patients with advanced-stage disease.

 

Downloads

Download data is not yet available.
Relationship between PD-L1 expression and prognostic factors in high- risk cutaneous squamous and basal cell carcinoma

Downloads

Published

2022-06-30

How to Cite

1.
Yülek Özden, Batur Şebnem, Özcan K, Yol C, Aydın Ülgen Övgü. Relationship between PD-L1 expression and prognostic factors in high-risk cutaneous squamous and basal cell carcinoma. Bosn J of Basic Med Sci [Internet]. 2022Jun.30 [cited 2022Aug.18];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/7574

Issue

Section

Pathology