ABO gene polymorphisms are associated with acute coronary syndrome and with plasma concentration of HDL-cholesterol and triglycerides

Authors

  • Gilberto Vargas-Alarcón Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, México https://orcid.org/0000-0001-7916-5163
  • Oscar Pérez-Méndez Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, México https://orcid.org/0000-0002-6977-1829
  • Rosalinda Posadas-Sánchez Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, México
  • Héctor González-Pacheco Unidad Coronaria, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, México
  • Alexandra Arias-Mendoza Unidad Coronaria, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, México https://orcid.org/0000-0002-5942-4102
  • Galileo Escobedo Unidad de Medicina Experimental, Hospital General de Mexico, Dr. Eduardo Liceaga, Mexico City, México https://orcid.org/0000-0002-9224-7400
  • Teresa Juárez-Cedillo Unidad de Investigación en Epidemiologia y Servicios de Salud-Área de Envejecimiento. Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, México https://orcid.org/0000-0002-9442-3471
  • Marva Arellano-González Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, México
  • José Manuel Fragoso Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, México https://orcid.org/0000-0003-3137-7815

DOI:

https://doi.org/10.17305/bb.2023.9244

Keywords:

Polymorphisms, acute coronary syndrome, human ABO blood group system

Abstract

The role of ABO gene polymorphisms in acute coronary syndrome (ACS) and lipid metabolism is increasingly recognized. We investigated whether ABO gene polymorphisms are significantly associated with ACS and the plasma lipid profile. Six ABO gene polymorphisms (rs651007 T/C, rs579459 T/C, rs495928 T/C, rs8176746 T/G, rs8176740 A/T, and rs512770 T/C) were determined by 5’exonuclease TaqMan assays in 611 patients with ACS and 676 healthy controls. The results demonstrated that the rs8176746 allele was associated with a lower risk of ACS under the co-dominant, dominant, recessive, over-dominant, and additive models (= 0.0004, = 0.0002, = 0.039,  = 0.0009, and = 0.0001, respectively). Furthermore, under co-dominant, dominant, and additive models, the rs8176740 allele was associated with a lower risk of ACS (= 0.041, = 0.022, and = 0.039, respectively). On the other hand, the rs579459 C allele was associated with a lower risk of ACS under the dominant, over-dominant, and additive models (= 0.025, = 0.035, and = 0.037, respectively). In a subanalysis performed with the control group, rs8176746 and rs8176740 alleles were associated with low systolic blood pressure and with both high high-density lipoprotein-cholesterol (HDL-C) and low triglyceride plasma concentrations, respectively. In conclusion, ABO gene polymorphisms were associated with a lower risk of ACS, and lower systolic blood pressure and plasma lipid levels, suggesting a causal relationship between ABO blood groups and the incidence of ACS.

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ABO gene polymorphisms are associated with acute coronary syndrome and with plasma concentration

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Published

03-11-2023

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Translational and Clinical Research

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How to Cite

1.
ABO gene polymorphisms are associated with acute coronary syndrome and with plasma concentration of HDL-cholesterol and triglycerides. Biomol Biomed [Internet]. 2023 Nov. 3 [cited 2024 Apr. 25];23(6):1125–1135. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/9244