Parathyroid hormone-related protein as a potential prostate cancer biomarker: Promoting prostate cancer progression through upregulation of c-Met expression

Authors

  • Yan Zhao Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China; Department of Urology, Xuzhou Cancer Hospital, Affiliated Hospital of Jiangsu University, Xuzhou, China https://orcid.org/0000-0001-9673-0494
  • Zhen-Yu Fu Department of Urology, Changshu No.2 People’s Hospital, Changshu, China
  • Han-Yong Feng Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China
  • Yu-Hao Peng Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China
  • Zhi-Xiang Yin Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China
  • Jing-Yi Cao Department of Urology, Xuzhou Cancer Hospital, Affiliated Hospital of Jiangsu University, Xuzhou, China
  • Chang-Song Pei Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China

DOI:

https://doi.org/10.17305/bb.2023.9753

Keywords:

Parathyroid hormone-related protein (PTHrP), mesenchymal-epithelial transition factor (c-Met), clinicopathological parameter, prostate cancer

Abstract

Parathyroid hormone-related protein (PTHrP) plays a significant role in various tumor types, including prostate cancer. However, its specific role and underlying mechanisms in prostate cancer remain unclear. This study investigates the role of PTHrP and its interaction with the c-Met in prostate cancer. PTHrP was overexpressed and knocked down in prostate cancer cell lines to determine its effect on cell functions. Xenograft tumor models were employed to assess the impact of PTHrP overexpression on tumor growth. To delve into the interaction between PTHrP and c-Met, rescue experiments were conducted. Clinical data and tissue samples from prostate cancer patients were gathered and analyzed for PTHrP and c-Met expression. PTHrP overexpression in prostate cancer cells upregulates c-Met expression and augments cell functions. In contrast, PTHrP-knockdown diminishes c-Met expression and inhibits cell functions. In vivo experiments further demonstrated that PTHrP overexpression promoted tumor growth in xenograft models.Moreover, modulating c-Met expression in rescue experiments led to concurrent alterations in prostate cancer cell functions. Immunohistochemical analysis of clinical samples displayed a significant positive correlation between PTHrP and c-Met expression. Additionally, PTHrP expression correlated with clinical parameters like prostate-specific antigen (PSA) levels, tumor stage, lymph node involvement, distant metastasis, and Gleason score. PTHrP plays a crucial role in prostate cancer progression by upregulating c-Met expression. These insights point to PTHrP as a promising potential biomarker for prostate cancer.

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Parathyroid hormone-related protein as a potential prostate cancer biomarker: Promoting prostate cancer progression through upregulation of c-Met expression

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Published

11-03-2024

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Section

Translational and Clinical Research

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How to Cite

1.
Parathyroid hormone-related protein as a potential prostate cancer biomarker: Promoting prostate cancer progression through upregulation of c-Met expression. Biomol Biomed [Internet]. 2024 Mar. 11 [cited 2024 Jun. 20];24(2):374–386. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/9753