Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins

  • Radivoj Jadrić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Sabaheta Hasić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Emina Kiseljaković Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Jovan Radovanović Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Emina Ićindić-Nakaš Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Mira Winterhalter-Jadrić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Keywords: amitryptilin, beta-endorphins, rat, sera, brain

Abstract

The aim of our study was to establish the influence of antidepressive drugs on serum and brain beta-endorphins in experimental animals. Experiment was performed on albino Wistar rats. Antidepressant amitryptiline was used, and for quantification of sera and brain beta-endorphins RIA technique. Our results showed difference between sera and brain beta-endorphins concentration in amitryptiline pretreated animals, vs. those in serum and brain of control group treated with 0.95% NaCl. This study shows that use of psychoactive drugs have influence on sera and brain beta-endorphins concentration. Beta-endorphins could be of great importance, used as markers for evaluation of antidepressant drug effects.

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Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins
Published
2006-11-20
How to Cite
1.
Jadrić R, Hasić S, Kiseljaković E, Radovanović J, Ićindić-Nakaš E, Winterhalter-Jadrić M. Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins. Bosn J of Basic Med Sci [Internet]. 2006Nov.20 [cited 2020Oct.29];6(4):64-6. Available from: http://www.bjbms.org/ojs/index.php/bjbms/article/view/3124
Section
Biochemistry