The Effects of Combined Insulin and Metformin Therapy in Obese Patients with Diabetes Mellits Type 2 in the Early Stage of the Disease

Authors

  • Belma Aščić - Buturović Clinic of Endocrinology, Diabetes and Metabolic Diseases, Sarajevo University Clinics Center

DOI:

https://doi.org/10.17305/bjbms.2006.3173

Keywords:

insulin therapy, obese patients, diabetes mellitus type 2

Abstract

Combination of insulin and metformin has been shown to improve glycaemic control in clinical trials, particularly in obese patients with diabetes type 2. Insulin therapy can improve function of pancreatic beta cells and periphery insulin activity in target cells in order to enhance glycaemic homeostasis (1, 2, 3). In our study we included obese patients with diabetes type 2 in the early stage of the disease. The study is partially retrospective and partially prospective. The study encompassed 40 patients split in two groups. The first group of 20 patients received insulin therapy combined with metformin, while the patients of the second group were treated with oral antidiabetic drugs, sulfonylureas and metformin. Three months later, the group treated with insulin and metformin showed improvement in the monitored parameters, namely significant reduction in HbA1c (p = 0.003), MFBG (p = 0.0009), PPG (p = 0.028). Insulin therapy administered together with metformin, in obese patients with diabetes type 2, in the early stage of the disease, resulted in well regulated fasting blood glycaemia, as well as post challenge glycaemia and HbA1c.

Downloads

Download data is not yet available.
The Effects of Combined Insulin and Metformin Therapy in Obese Patients with Diabetes Mellits Type 2 in the Early Stage of the Disease

Downloads

Published

2006-05-20

How to Cite

1.
Aščić - Buturović B. The Effects of Combined Insulin and Metformin Therapy in Obese Patients with Diabetes Mellits Type 2 in the Early Stage of the Disease. Bosn J of Basic Med Sci [Internet]. 2006May20 [cited 2022Dec.3];6(2):54-8. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3173

Issue

Section

Translational and Clinical Research