Nitric Oxide in Serum and Renal Tissue During Compensatory Renal Hypertrophy in Rats

  • Jasminko Huskić Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Asija Začiragić Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Nermina Babić Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Nedžad Mulabegović Institute of Pharmacology, Faculty of Medicine, University of Sarajevo
Keywords: nitric oxide, serum, renal tissue, unilateral nephrectomy

Abstract

Nitric oxide (NO) level in serum and renal tissue has been examined in 15 male Wistar rats, body weight 200-250 g, 7 days after unilateral nephrectomy. All rats were ether-anaesthetized and the kidneys were removed by dorsolateral approach. NO concentration in serum and renal tissue was determined by classic colorimetric Griess reaction. Conversion of NO(3)(2-) into NO(2)(2-) was done with elementary zinc. Results have shown that NO concentration in renal tissue is statistically higher in rats 7 days after unilateral nephrectomy then in control renal tissue before compensatory kidney growth (p<0,02). There is no difference between NO concentration in serum before unilateral nephrectomy and 7 days after nephrectomy. These findings suggest that NO may play an important role in mediating the hemodynamic changes associated with reduced renal mass.

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Published
2006-02-20
How to Cite
1.
Huskić J, Začiragić A, Babić N, Mulabegović N. Nitric Oxide in Serum and Renal Tissue During Compensatory Renal Hypertrophy in Rats. Bosn J of Basic Med Sci [Internet]. 2006Feb.20 [cited 2019Apr.19];6(1):46-9. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3209
Section
Biochemistry

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