Application of microfluidic chips in anticancer drug screening

  • Xin-yue Fan Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
  • Zhuo-fen Deng Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
  • Yan-yan Yan School of Medicine, Shanxi Datong University, Datong, China.
  • Valerii E. Orel National Cancer Institute, Kyiv, Ukraine ; National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kyiv, Ukraine.
  • Andrii Shypko National Cancer Institute, Kyiv, Ukraine.
  • Valerii B. Orel National Cancer Institute, Kyiv, Ukraine. ; National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kyiv, Ukraine.
  • Donika Ivanova Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria.
  • Christian Pilarsky Department of Surgery, Friedrich-Alexander University of Erlangen- Nuremberg (FAU) and University Hospital of Erlangen, Erlangen, Germany.
  • Jing Tang Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki FI-00290, Finland https://orcid.org/0000-0001-7480-7710
  • Zhe-Sheng Chen Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY, United States https://orcid.org/0000-0002-8289-097X
  • Jian-ye Zhang Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, P.R. China https://orcid.org/0000-0001-5242-3687
Keywords: Microfluidic chip, anticancer drug screening, high throughput screening

Abstract

With the continuous development of drug screening technology, new screening methodologies and technologies are constantly emerging, driving drug screening into rapid, efficient and high-throughput development. Microfluidics is a rising star in the development of innovative approaches in drug discovery. In this article, we summarize the recent years' progress of microfluidic chip technology in drug screening, including the developmental history, structural design, and applications in different aspects of microfluidic chips on drug screening. Herein, the existing microfluidic chip screening platforms are summarized from four aspects: chip structure design, sample injection and drive system, cell culture technology on a chip, and efficient remote detection technology. Furthermore, this review discusses the application and developmental prospects of using microfluidic chips in drug screening, particularly in screening natural product anticancer drugs based on chemical properties, pharmacological effects, and drug cytotoxicity.

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Application of microfluidic chips in anticancer drug screening
Published
2021-09-30
How to Cite
1.
Fan X- yue, Deng Z- fen, Yan Y- yan, E. Orel V, Shypko A, B. Orel V, Ivanova D, Pilarsky C, Tang J, Chen Z-S, Zhang J- ye. Application of microfluidic chips in anticancer drug screening. Bosn J of Basic Med Sci [Internet]. 2021Sep.30 [cited 2021Oct.28];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/6484
Section
Reviews