Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis

Authors

  • Xiaoyang Tao Orthopedics Department, Ordos Central Hospital, Ordos, China
  • Wupeng Yang Orthopedics Department, Ordos Central Hospital, Ordos, China
  • Qinxin Zhang Orthopedics Department, Ordos Central Hospital, Ordos, China
  • Yongjiang Wang Orthopedics Department, Ordos Central Hospital, Ordos, China
  • Feng Gao Orthopedics Department, Ordos Central Hospital, Ordos, China
  • Yuehan Wang Ordos No.1 Middle School, Ordos, China
  • Tingxin Zhang Orthopedics Department, Ordos Central Hospital, Ordos, China
  • Hao Liu Orthopedics Department, Ordos Central Hospital, Ordos, China
  • Jindong Chen Ordos School of Clinical Medicine, Inner Mongolia Medical University, Ordos, China

DOI:

https://doi.org/10.17305/bb.2024.10449

Keywords:

vitamin D3, 25(OH)D, oral, load dose, intermittent, elderly

Abstract

Vitamin D is commonly used to prevent and treat osteoporosis, with studies indicating its potential to reduce fractures, falls, and mortality. However, meta-analyses present inconsistent findings regarding its efficacy, particularly reflecting significant variability in data and outcomes related to various dosing regimens. In this meta-analysis, we assessed the impact of high-dose intermittent oral administration of vitamin D3 on serum 25(OH)D levels, fractures, falls, and mortality among elderly individuals. We included 14 randomized controlled trials (RCTs) and employed Review Manager 5.4 for statistical analysis. Our findings indicate that intermittent monthly administration of vitamin D3 (over 800 IU per day) significantly raised serum 25(OH)D levels at all timepoints after six months, maintaining levels above 75 nmol/L throughout the year. This regimen showed no increase in all-cause mortality, with a risk ratio (95% CI) of 0.95 (0.87-1.04). Likewise, it did not significantly reduce the risks of falls and fractures, with risk ratios of 1.02 (0.98-1.05) and 0.95 (0.87-1.04) respectively. Although one-year intermittent administration significantly increased the concentration of 25(OH)D in serum, further research is needed to determine if this method would increase the incidence of falls. Therefore, it is not recommended at this stage due to the lack of demonstrated safety in additional relevant RCTs. This study had been registered on PROSPERO (CRD42022363229).

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Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis

Published

13-04-2024

Issue

Section

Reviews

Categories

How to Cite

1.
Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis. Biomol Biomed [Internet]. 2024 Apr. 13 [cited 2024 May 26];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/10449