Drosophila melanogaster models for investigating inflammatory bowel disease: Methods, pathology, mechanisms, and therapeutic approaches

Authors

  • Xinyi Li School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, China
  • Shushen Sun Department of Gastroenterology, Tianjin University Jinnan Hospital, Tianjin, China
  • Xiaoxi Liu First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • Qinghao Meng School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, China
  • Mengzhe Tian School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, China
  • Jingyi Li School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, China
  • Suxia Ren School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China
  • Zengyi Huang National Clinical Research Center for Child Health and Disorders, Children’s Hospital of Chongqing Medical University, Chongqing, China
  • Yiwen Wang School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, China
  • Shaoshan Du Department of Gastroenterology, Tianjin University Jinnan Hospital, Tianjin, China

DOI:

https://doi.org/10.17305/bb.2025.12656

Keywords:

Inflammatory bowel disease , IBD, Drosophila melanogaster, gut microbiota, intestinal stem cells, ISC, inflammatory pathways, natural products

Abstract

Inflammatory bowel disease (IBD) is a complex disorder characterized by chronic gastrointestinal inflammation. This paper examines the use of Drosophila melanogaster as a model organism to investigate interactions among the gut microbiota, intestinal stem cells (ISCs), and signaling pathways involved in IBD pathogenesis. Key findings indicate that dysbiosis of the gut microbiota significantly contributes to IBD by altering immune responses and inflammatory signaling, leading to increased intestinal damage. Additionally, ISCs are crucial for intestinal regeneration; their dysregulation exacerbates injury, highlighting their role in maintaining gut homeostasis. Natural compounds, particularly those derived from traditional herbal medicines, show promise in alleviating IBD symptoms by targeting oxidative stress, regulating inflammation, and modulating autophagy, thus promoting ISC homeostasis and restoring microbial balance. This review underscores the intricate relationships among the gut microbiota, ISCs, and inflammatory pathways in IBD, as elucidated through Drosophila studies. The studies summarized here emphasize the need to address microbial imbalances, ISC dysregulation, and inflammatory mechanisms to develop effective therapeutic strategies. Further research is essential to fully elucidate these interactions and inform innovative treatments that improve patient outcomes in IBD management.

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Drosophila melanogaster models for investigating inflammatory bowel disease: Methods, pathology, mechanisms, and therapeutic approaches

Published

01-07-2025

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Section

Review

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How to Cite

1.
Drosophila melanogaster models for investigating inflammatory bowel disease: Methods, pathology, mechanisms, and therapeutic approaches. Biomol Biomed [Internet]. 2025 Jul. 1 [cited 2025 Jul. 3];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/12656