Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial Infarction

  • Larisa Dizdarević-Hudić Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
  • Zumreta Kušljugić Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
  • Fahir Baraković Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
  • Selmira Brkić Department of Pathophysiology, Faculty of Medicine, University of Tuzla
  • Damir Sabitović Department of Immunology and Microbiology, University Clinics Centre Tuzla
  • Elmir Jahić Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
  • Maida Isabegović Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
  • Elnur Smajić Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
  • Igor Hudić Divison of Reproductive Immunology, Clinic for Gynaecology and Obstetrics, University Clinics Centre Tuzla
  • Katarina Divković Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
Keywords: cytokines, anti-inflammatory, pro-inflammatory, HDL, acute myocardial infarction

Abstract

The aim of this study was to analyze (i) ratios between pro-inflammatory cytokines interleukin 6 (IL-6), interleukin 1 (IL-1), tumour necrosis factor α (TNF-α) and anti-inflammatory cytokine interleukin 10 (IL-10) in patients with acute myocardial infarction (AMI) and stable angina pectoris (ii) as well as correlation between IL-6 and IL-10 in AMI and (iii) correlation between IL-6 and lipoproteins in AMI.

The total of 71 patients were enrolled in this study, 41 of them with AMI (study group) and 30 with stable angina pectoris (control group). The concentrations of cytokines and lipoproteins were measured from blood samples. Pro-inflammatory to anti-inflammatory cytokine ratios were calculated by dividing concentrations of pro-inflammatory cytokines with IL-10. In statistical analyses we used descriptive statistics, normality tests and analysis of correlation.

IL-6: IL-10 ratio is significantly higher in AMI than in stable angina (P < 0,001), TNF-α: IL-10 is also higher in study group but the difference is not significant. We found positive linear correlation between IL-6 and IL-10 (r =0,43; p = 0,015) and negative linear correlation between IL-6 and high density lipoprotein HDL (r = -0,47; p= 0,008) in AMI.

IL-6: IL-10 ratio is higher in AMI than in stable angina. There is linear correlation between IL-6 and IL-10 and IL-6 and HDL in AMI.

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Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial Infarction
Published
2009-11-20
How to Cite
1.
Dizdarević-HudićL, Kušljugić Z, Baraković F, Brkić S, Sabitović D, Jahić E, Isabegović M, Smajić E, Hudić I, Divković K. Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial Infarction. Bosn J of Basic Med Sci [Internet]. 2009Nov.20 [cited 2021Jan.26];9(4):301-6. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2784
Section
Translational and Clinical Research