Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial Infarction

Larisa Dizdarević-Hudić; Zumreta Kušljugić; Fahir Baraković; Selmira Brkić; Damir Sabitović; Elmir Jahić; Maida Isabegović; Elnur Smajić; Igor Hudić; Katarina Divković

doi:10.17305/bjbms.2009.2784

Authors

Larisa Dizdarević-Hudić Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
Zumreta Kušljugić Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
Fahir Baraković Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
Selmira Brkić Department of Pathophysiology, Faculty of Medicine, University of Tuzla
Damir Sabitović Department of Immunology and Microbiology, University Clinics Centre Tuzla
Elmir Jahić Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
Maida Isabegović Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
Elnur Smajić Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla
Igor Hudić Divison of Reproductive Immunology, Clinic for Gynaecology and Obstetrics, University Clinics Centre Tuzla
Katarina Divković Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla

DOI:

https://doi.org/10.17305/bjbms.2009.2784

Keywords:

cytokines, anti-inflammatory, pro-inflammatory, HDL, acute myocardial infarction

Abstract

The aim of this study was to analyze (i) ratios between pro-inflammatory cytokines interleukin 6 (IL-6), interleukin 1 (IL-1), tumour necrosis factor α (TNF-α) and anti-inflammatory cytokine interleukin 10 (IL-10) in patients with acute myocardial infarction (AMI) and stable angina pectoris (ii) as well as correlation between IL-6 and IL-10 in AMI and (iii) correlation between IL-6 and lipoproteins in AMI.

The total of 71 patients were enrolled in this study, 41 of them with AMI (study group) and 30 with stable angina pectoris (control group). The concentrations of cytokines and lipoproteins were measured from blood samples. Pro-inflammatory to anti-inflammatory cytokine ratios were calculated by dividing concentrations of pro-inflammatory cytokines with IL-10. In statistical analyses we used descriptive statistics, normality tests and analysis of correlation.

IL-6: IL-10 ratio is significantly higher in AMI than in stable angina (P < 0,001), TNF-α: IL-10 is also higher in study group but the difference is not significant. We found positive linear correlation between IL-6 and IL-10 (r =0,43; p = 0,015) and negative linear correlation between IL-6 and high density lipoprotein HDL (r = -0,47; p= 0,008) in AMI.

IL-6: IL-10 ratio is higher in AMI than in stable angina. There is linear correlation between IL-6 and IL-10 and IL-6 and HDL in AMI.