Role of Meconium in the Reaction of Airways Smooth Musculature in the Newborn with Meconium Aspiration Syndrome (Mas).

  • Hilmi Islami Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinics Center
  • Sadi Bexheti Department of Anatomy, Faculty of Medicine, University of Prishtina, Clinics Centre
  • Ragip Shabani Department of Pathology, Faculty of Medicine, University of Prishtina, Clinics Centre
  • Bajram Nuraj Department of Anatomy, Faculty of Medicine, University of Prishtina, Clinics Centre
  • Fehmi Zeqiri Department of Gynecology, Faculty of Medicine, University of Prishtina, Clinics Centre
  • Aziz Šukalo Drugs Factory “Bosnalijek dd”
  • Ilir Kurtishi Department of Physiology, Faculty of Medicine, University of Prishtina, Clinical Centre
  • Skender Kutllovci Drugs Factory “Bosnalijek dd”
  • Hasime Qorraj Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinics Center
  • Mentor Disha Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinics Center
Keywords: Trachea, meconium, dopamine, serotonine, ethanol

Abstract

The role of meconium in the respiratory system was studied in newborns, who died from various causes (250 up to 3000 g of weight). We monitored tracheal rings response to dopamine, serotonin and ethanol in different concentrations (dopamine: 0,05 mg/ml, 0,5 mg/ml, 5 mg/ml; serotonin (5-HT): 10-4, 10-3, 10-2, 10-1 mol/dm3; ethanol: 0,02 ml, 0,5 ml, 1,0 ml; 96%). Tracheal smooth musculature tonus (TSM) was examined in 48 tracheal preparations taken after the newborn exitus due to different reasons. Based on functional researche of isolated preparations of tracheas, it may be concluded that: aspiration of me-conium has not changed the response of TSM to dopamine, serotonin and ethanol (p>0,1) in comparison with the control group, which have died due to different lung inflammatory processes (e.g. pneumonia, bronchopneumonia, atelectasis, cerebral hemorrhage). The results suggest that meconium does not potentiate the constricting action of dopamine, serotonin and ethanol in tracheobronchial system. Meconium causes mild relaxation of the TSM through a mechanism that is not intermediated by the products of cyclooxygenases (prostaglandins, prostacyclins) from the tracheal epithelium or proteins. Also, as it seems, the direct activity of many tested acids in the smooth musculature has no significant impact on increase of the airways tonus in MAS syndrome.

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Role of Meconium in the Reaction of Airways Smooth Musculature in the Newborn with Meconium Aspiration Syndrome (Mas).
Published
2009-11-20
How to Cite
1.
Islami H, Bexheti S, Shabani R, Nuraj B, Zeqiri F, Šukalo A, Kurtishi I, Kutllovci S, Qorraj H, Disha M. Role of Meconium in the Reaction of Airways Smooth Musculature in the Newborn with Meconium Aspiration Syndrome (Mas). Bosn J of Basic Med Sci [Internet]. 2009Nov.20 [cited 2021Oct.28];9(4):342-8. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2791
Section
Translational and Clinical Research