Letter regarding “Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis”
We have read with a great interest the article by Gupta et al.  who performed a meta-analysis exploring the association between chronic mechanical irritation and oral squamous cell carcinoma. The conclusion of the meta-analysis is that chronic oral mucosa irritation has a significant association with oral squamous cell carcinoma, and the nature of association could be that of a potential co-factor (dependent risk factor) rather than an independent risk factor.
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