The Influence of Risk Factors in Remodelling Carotid Arteries in Patients Undergoing Peritoneal Dialysis

  • Damir Rebić Clinic for Nephrology, University of Sarajevo Clinics Centre
  • Senija Rašić Clinic for Nephrology, University of Sarajevo Clinics Centre
  • Snežana Unčanin Clinic for Nephrology, University of Sarajevo Clinics Centre
  • Jasminka Džemidžić Clinic for Nephrology, University of Sarajevo Clinics Centre
  • Alma Muslimović Institute of Genetic, Faculty of Medicine, University of Sarajevo
  • Amra Ćatović Institute of Genetic, Faculty of Medicine, University of Sarajevo
  • Aida Mujaković Clinic for Nephrology, University of Sarajevo Clinics Centre
Keywords: BEN, Bosnia, endemic, non-endemic, family burden, GFR

Abstract

Accelerated atherosclerosis and vascular calcification, with oxidative stress, endothelial dysfunction, and other factors causing the arterial stiffness, increases cardiovascular morbidity and mortality in patients on peritoneal dialysis. The aim of this paper is to assess changes in intima media thickness (IMT) at common carotid arteries (CCA) in patients with stable continuous ambulatory peritoneal dialysis (PD) and examine the relationship of these changes and other risk factors on the occurrence of atherosclerosis. The study was conducted on 35 stable PD patients (25 type 2 diabetic patients), aged 58,6 ± 10’6 years. CCA-IMT was assessed using ultrasound B-mode technique, bilaterally. Other risk factors for the occurrence of atherosclerosis were monitored through regular laboratory control. One atheromatous plaque was found in 19 patients (54,3%). Among 25 type 2 diabetic patients, vascular calcifications were found in 80% patients. In all PD patients, CCA-IMT is 0,77 ± 0,23, in PD patients with vascular calcifications CCA-IMT is 1,05 ± 0,2 mm, while in group without vascular calcifications the value of this parameter is 0,56 ± 0,09 (p<0,01). Significant differences were found between PD patients with and without vascular calcifications on CCA in patients age (p<0,001), as well as values of systolic blood pressure (p=0,001), serum phosphorus (p=0,017), product calcium and phosphorus (p=0,021), CRP (p=0,039), triglycerides (p<0,05) and lipoprotein (a) values (p=0,044). Our results suggest an important determination of common carotid arteries intima media thickness and its relation to other risk factors for the occurrence and progression of atherosclerosis in patients undergoing peritoneal dialysis.

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The Influence of Risk Factors in Remodelling Carotid Arteries in Patients Undergoing Peritoneal Dialysis
Published
2010-04-20
How to Cite
1.
Rebić D, Rašić S, Unčanin S, Džemidžić J, Muslimović A, Ćatović A, Mujaković A. The Influence of Risk Factors in Remodelling Carotid Arteries in Patients Undergoing Peritoneal Dialysis. Bosn J of Basic Med Sci [Internet]. 2010Apr.20 [cited 2020Sep.28];10(1):S79-S82. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2654
Section
Translational and Clinical Research