Micophenolat Mofetil Versus Azathioprine: Effects on Renal Graft Function in Early Posttransplant Period

  • Farid Ljuca Department of Physiology, Faculty of Medicine, University of Tuzla
  • Semir Imamović Department of Anaesthesiology and Reanimatology, University Clinical Centre Tuzla
  • Dešo Mešić Department of Surgery, University Clinical Centre Tuzla
  • Šefik Hasukić Department of Surgery, University Clinical Centre Tuzla
  • Safet Omerović Regional Medical Centre, "Dr Safet Mujić"Regional Medical Centre, “Dr Safet Mujić’
  • Mustafa Bazardžanović Regional Medical Centre, “Dr Safet Mujić’
  • Fatima Iljazagić-Halilović Department of Physiology, Faculty of Medicine, University of Tuzla
Keywords: immunosuppression, MMF, AZA, renal graft function

Abstract

All conventional immunosuppressive tree drugs-protocols are based on Cyclosporine; consisting of low doses of Cyclosporine (CsA), Azathioprine (AZA) or Mycophenolate Mofetil (MMF) and Prednisolone, AZA has been used in clinical transplantation for more than 30 years and was the first immunosuppres-sive agent to achieve widespread use in organ transplantation. MMF was introduced in clinical practice in 1995 after several clinical trials proved that it was more efficient than AZA for prevention of acute rejection episodes. Our aim was to evaluate influence of AZA and MMF on renal graft function in early post-transplant stage. Study recruited 74 patients who underwent kidney transplantation in University Clinical Centre Tuzla. All patients received CsA and corticosteroid-based immunosuppression, as a part of triple immunosuppressive regiment, 40 patients received AZA and 34 MMF. In order to assess renal graft function, following parameters were evaluated: glomerular filtration rate GFR (ml/min) creatinine clearance (CrCl) (ml/min), 24 h urine output (ml/day), and from the serum potassium, sodium, urea and creatinine (mmol/dm3). Significantly higher average values of 24 hour urine output were recorded during first seven postoperative days in patients receiving MMF compared to those treated with AZA. Serum creatinine values showed statistically significant decrease, starting with the second postoperative day, in MMF vs. AZA group (168,7±70,5 vs. 119,9±42,6; p<0,0007). GFR was significantly higher in MMF compared to the AZA group of patients. On the first post-transplant day CrCl was higher in AZA group (24,3±10 vs. 17,5±7,3; p=0,01), next six days situation is reversed CrCl is significantly higher in the MMF group (43,7±15 vs. 53, 4±22, 8 p=0,006). MMF vs. AZA therapy was associated with protective effect against worsening of renal function in first seven post-transplant days.

Downloads

Download data is not yet available.
Published
2009-05-20
How to Cite
1.
Ljuca F, Imamović S, Mešić D, Hasukić Šefik, Omerović S, Bazardžanović M, Iljazagić-Halilović F. Micophenolat Mofetil Versus Azathioprine: Effects on Renal Graft Function in Early Posttransplant Period. Bosn J of Basic Med Sci [Internet]. 2009May20 [cited 2019Jun.18];9(2):156-60. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2836
Section
Pharmacology

Most read articles by the same author(s)