The Synthesis and Antimicrobial Activity of Some 4-Hydroxycoumarin Derivatives

  • Davorka Završnik Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo
  • Samija Muratović Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo
  • Selma Špirtović Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo
  • Dženita Softić Institute for Quality Control of Medicines
  • Marica Medić-Šarić Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb
Keywords: dimers, tetramers, derivatives of 4-hydroxycoumarin, antimicrobial activity, minimal inhibition concentration, MIC, minimal bactericidal concentration, MBC

Abstract

Due to exceptional reactivity of 4-hydroxycoumarin, the synthesis of new coumarin derivatives of dimer and tetramer type has been carried out. The synthesis was carried out from 4-hydroxycoumarin and various aromatic aldehydes. In this way, compounds of the dimer 3,3’-(benzilidene)bis (4-hydroxycoumarin) type, as well as of the tetramer 3,3,’3’,’3’’’-(1,4-dim- ethylenphenyl)tetra (4-hydroxycoumarin) type were prepared.

The newly synthesized derivatives contain different functional groups, and as such they could exhibit microbiological activity. Therefore, we tested the microbiological activity of these derivatives on various species of bacteria and fungi. The tested compounds have shown different activity in terms of growth inhibition of microorganisms. Newly synthesized derivatives exhibit antibacterial activities, manifested as growth inhibition on Grampositive bacteria types (Bacillus, Staphylococcus), while the activity against Candida was much weaker. The same compound did not show any antimicrobial activity against two Gram-negative bacteria types (Escherichia coli, Pseudomonas aeruginosa). The compound 1 showed the best microbiological activity. The obtained results confirmed its good antibacterial and antimycotic activities against different microorganisms.

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The Synthesis and Antimicrobial Activity of Some 4-Hydroxycoumarin Derivatives
Published
2008-08-20
How to Cite
1.
Završnik D, Muratović S, Špirtović S, Softić D, Medić-Šarić M. The Synthesis and Antimicrobial Activity of Some 4-Hydroxycoumarin Derivatives. Bosn J of Basic Med Sci [Internet]. 2008Aug.20 [cited 2021Sep.20];8(3):277-81. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/2933
Section
Pharmacology