Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes Mellitus

  • Asija Začiragić Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Jasminko Huskić Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Almira Hadžović-Džuvo Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Amina Valjevac Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Nesina Avdagić Institute of Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Nedžad Mulabegović Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Sarajevo
Keywords: serum C-reactive protein, adiposity, type 2 diabetes mellitus

Abstract

We investigated serum concentration of C-reactive protein (CRP) and measures of adiposity in 30 patients with type 2 diabetes mellitus (15 male, 15 female) and 30 age and sex-matched apparently healthy subjects.

CRP concentration was determined by laser nephelometry (BN II Analyzer) and CardioPhase high-sensitivity CRP (DADE BEHRING) was used as reagent which consists of polystyrene particles coated with mouse monoclonal antibodies to CRP.

Results have shown that serum CRP concentration in patients with type 2 diabetes mellitus was statistically significantly higher compared to control group of healthy subjects (p<0,05). Body mass index (BMI) correlated significantly with serum concentration of CRP in patients with type 2 diabetes mellitus (r=0,614; p<0,001). Statistically significant positive correlation was also found between waist to hip ratio and serum CRP concentration in patients with type 2 diabetes mellitus (r=0,426; p<0,05).

Elevated serum CRP concentration in patients with type 2 diabetes mellitus is probably caused by the presence of chronic low-grade inflammation in these patients. It is possible that determined increase of CRP concentration reflects activation of innate immune system components in patients with type 2 diabetes mellitus. Implications of established association between measures of adiposity and serum CRP level in type 2 diabetes mellitus remain unclear.

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Published
2007-11-20
How to Cite
1.
Začiragić A, Huskić J, Hadžović-Džuvo A, Valjevac A, Avdagić N, Mulabegović N. Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes Mellitus. Bosn J of Basic Med Sci [Internet]. 2007Nov.20 [cited 2019Oct.15];7(4):322-7. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3021
Section
Biochemistry

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