Intensive Observation of Toxic Side Effects After Several-Year of Cyclosporin Treatment in Kidney Transplant Patient

  • Mensura Ašćerić Department of Pharmacology and Toxicology, Faculty of Medicine, University of Tuzla
  • Sevleta Avdić Department of Pharmacology and Toxicology, Faculty of Medicine, University of Tuzla
  • Sabrija Nukić Department of Pharmacology and Toxicology, Faculty of Medicine, University of Tuzla
  • Muamera Vrabac-Mujčinagić Department of Pharmacology and Toxicology, Faculty of Medicine, University of Tuzla
Keywords: concentration, cyclosporine, kidney transplant, toxic side effects

Abstract

In this work we are going to show results of intensive observation of adverse reactions of cyclosporine therapy during 18 months. The research was applied on 30 patients with kidney transplant. The medium time of kidney transplant survival was 9,7+/-2,3 years, with time span of 6 to 15 years. All the patients were subjects to several years' cyclosporine treatment, which was applied on a daily basis with a dosage of 2 to 5 mg/kg of body weight. The concentration of cyclosporine in blood was measured once a month. The concentration of cyclosporine in blood in 19 patients was in referent values of 122,50 nag/ml up to 280,50 nag/ml of blood. In 4 of the patients the concentration was heightened up to 370 to 538 nag/ml (X=766,37 nag/ml), and in 7 patients cyclosporine was below normal dosage down to 30,78 to 96,30 nag/ml in blood (x=77,12 nag/ml). We noticed these toxic side effects: increased values of systolic and diastolic arterial blood pressure in 5 patients, neurotoxic tremor effects in 4 patients, hyperplasia gingival and hirsute in 1 patient each.

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Intensive Observation of Toxic Side Effects After Several-Year of Cyclosporin Treatment in Kidney Transplant Patient
Published
2007-05-20
How to Cite
1.
Ašćerić M, Avdić S, Nukić S, Vrabac-MujčinagićM. Intensive Observation of Toxic Side Effects After Several-Year of Cyclosporin Treatment in Kidney Transplant Patient. Bosn J of Basic Med Sci [Internet]. 2007May20 [cited 2020Nov.27];7(2):134-7. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3067
Section
Pharmacology