Zearalenone-induced Lymphophagocytosis (T Cell Apoptosis) on the Rat’s Thymus

  • Mirsad Dorić Institute of Pathology, Faculty of Medicine, University of Sarajevo
  • Svjetlana Radović Institute of Pathology, Faculty of Medicine, University of Sarajevo
  • Mirsad Babić Institute of Pathology, Faculty of Medicine, University of Sarajevo
  • Suada Kuskunović Institute of Pathology, Faculty of Medicine, University of Sarajevo
  • Ivana Tomić Institute of Pathology, Faculty of Medicine, University of Sarajevo
  • Ivan Selak Institute of Pathology, Faculty of Medicine, University of Sarajevo
Keywords: apoptosis, lymphophagocytosis, thymus, zearalenone

Abstract

The effects of nonsteroidal mycotoxin zearalenone on the lymphoid tissue of thymus in a sense of investigating the subacute toxicity Wistar-albino rats have been examined in the course of the study. We analyzed 42 rats' specimens of both gender, treated with three dosage levels: 0,5; 2 and 4 mg/kg of body weight, after oral submission of the compound, and observed during three different time intervals: 10, 20 and 30 days. Microscopically was semiquantitatively determined lymphophagocytosis (apoptosis) and cortical thymic cellularity. It was percepted statistically significant growth of lymphophagocytosis compared to a dosage (p<0,01), as well as combination of dosage and interval (p<0,001), while gender had no statistically significant influence on tested parameter (p>0,05). Changes in cortical thyme cellularity were not percepted. Effects of applied doses of zearalenone on the lymphoid tissue of thymus were very mild and in correlation with estrogenicity. They are probably the result of interaction with estrogenic receptors.

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Published
2007-02-20
How to Cite
1.
Dorić M, Radović S, Babić M, Kuskunović S, Tomić I, Selak I. Zearalenone-induced Lymphophagocytosis (T Cell Apoptosis) on the Rat’s Thymus. Bosn J of Basic Med Sci [Internet]. 2007Feb.20 [cited 2019May20];7(1):66-0. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/3093
Section
Pathology

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