The impact of Ki-67 index, squamous differentiation, and several clinicopathologic parameters on the recurrence of low and intermediate-risk endometrial cancer

Authors

  • Birol Ocak Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0001-7537-1699
  • Fatma Öz Atalay Department of Surgical Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0002-7188-6115
  • Ahmet Bilgehan Sahin Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0002-7846-0870
  • Mine Ozsen Department of Surgical Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0002-5771-7649
  • Bahar Dakiki Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0001-9255-2475
  • Seray Türe Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Merve Mesohorli Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Hikmet Utku Odman Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Özgür Tanrıverdi Department of Medical Oncology, Faculty of Medicine, Sitki Kocman University, Mugla, Turkey https://orcid.org/0000-0002-0598-7284
  • Gökhan Ocakoğlu Department of Biostatistics, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0002-1114-6051
  • Mehmet Bayrak Department of Gynecologic Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0002-9910-8032
  • Hakan Ozan Department of Gynecologic Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Candan Demiröz Department of Radiation Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0003-1222-8822
  • Seda Sali Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Sibel Oyucu Orhan Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Adem Deligönül Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0002-3669-6391
  • Erdem Cubukcu Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Türkkan Evrensel Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

DOI:

https://doi.org/10.17305/bjbms.2020.5437

Keywords:

Low-intermediate risk, endometrioid endometrial carcinoma, recurrence, squamous differentiation, Ki-67

Abstract

Endometrial endometrioid carcinoma (EEC) represents approximately 75-80% of endometrial carcinoma cases. Three hundred and thirty-six patients with EEC followed-up in the authors’ medical center between 2010 and 2018 were included in our study. Two hundred and seventy-two low and intermediate EEC patients were identified using the European Society for Medical Oncology criteria and confirmed by histopathological examination. Recurrence was reported in 17 of these patients. The study group consisted of patients with relapse. A control group of 51 patients was formed at a ratio of 3:1 according to age, stage, and grade, similar to that in the study group. Of the 17 patients with recurrent disease, 13 patients (76.5%) were Stage 1A, and 4 patients (23.5%) were Stage 1B. No significant difference was found in age, stage, and grade between the case and control groups (p > 0.05). Body mass index, parity, tumor size, lower uterine segment involvement, SqD, and Ki-67 index with p<0.25 in the univariate logistic regression analysis were included in the multivariate analysis. Ki-67 was statistically significant in multivariate analysis (p = 0.018); however, there was no statistical significance in SqD and other parameters. Our data suggest that the Ki-67 index rather than SqD needs to be assessed for recurrence in patients with low- and intermediate-risk EEC.

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Author Biographies

  • Birol Ocak, Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Fatma Öz Atalay, Department of Surgical Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Surgical Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Ahmet Bilgehan Sahin, Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Mine Ozsen, Department of Surgical Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Surgical Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Bahar Dakiki, Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Seray Türe, Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Merve Mesohorli, Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Hikmet Utku Odman , Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Özgür Tanrıverdi, Department of Medical Oncology, Faculty of Medicine, Sitki Kocman University, Mugla, Turkey

    Department of Medical Oncology, Faculty of Medicine, Sitki Kocman University, Mugla, Turkey

  • Gökhan Ocakoğlu, Department of Biostatistics, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Biostatistics, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Hakan Ozan, Department of Gynecologic Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Gynecologic Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Candan Demiröz, Department of Radiation Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Radiation Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Seda Sali, Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Sibel Oyucu Orhan , Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Adem Deligönül, Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

  • Erdem Cubukcu, Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

The impact of Ki-67 index, squamous differentiation and several clinicopathologic parameters on the recurrence of low and intermediate-risk endometrial cancer

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Published

18-02-2021

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Section

Pathology

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How to Cite

1.
The impact of Ki-67 index, squamous differentiation, and several clinicopathologic parameters on the recurrence of low and intermediate-risk endometrial cancer. Biomol Biomed [Internet]. 2021 Feb. 18 [cited 2024 May 19];21(5):549-54. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/5437