The impact of Ki-67 index, squamous differentiation, and several clinicopathologic parameters on the recurrence of low and intermediate-risk endometrial cancer

  • Birol Ocak Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0001-7537-1699
  • Fatma Öz Atalay Department of Surgical Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0002-7188-6115
  • Ahmet Bilgehan Sahin Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0002-7846-0870
  • Mine Ozsen Department of Surgical Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0002-5771-7649
  • Bahar Dakiki Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0001-9255-2475
  • Seray Türe Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Merve Mesohorli Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Hikmet Utku Odman Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Özgür Tanrıverdi Department of Medical Oncology, Faculty of Medicine, Sitki Kocman University, Mugla, Turkey https://orcid.org/0000-0002-0598-7284
  • Gökhan Ocakoğlu Department of Biostatistics, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0002-1114-6051
  • Mehmet Bayrak Department of Gynecologic Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0002-9910-8032
  • Hakan Ozan Department of Gynecologic Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Candan Demiröz Department of Radiation Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0003-1222-8822
  • Seda Sali Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Sibel Oyucu Orhan Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Adem Deligönül Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey https://orcid.org/0000-0002-3669-6391
  • Erdem Cubukcu Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey
  • Türkkan Evrensel Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey
Keywords: Low-intermediate risk, endometrioid endometrial carcinoma, recurrence, squamous differentiation, Ki-67

Abstract

Endometrial endometrioid carcinoma (EEC) represents approximately 75-80% of endometrial carcinoma cases. Three hundred and thirty-six patients with EEC followed-up in the authors’ medical center between 2010 and 2018 were included in our study. Two hundred and seventy-two low and intermediate EEC patients were identified using the European Society for Medical Oncology criteria and confirmed by histopathological examination. Recurrence was reported in 17 of these patients. The study group consisted of patients with relapse. A control group of 51 patients was formed at a ratio of 3:1 according to age, stage, and grade, similar to that in the study group. Of the 17 patients with recurrent disease, 13 patients (76.5%) were Stage 1A, and 4 patients (23.5%) were Stage 1B. No significant difference was found in age, stage, and grade between the case and control groups (p > 0.05). Body mass index, parity, tumor size, lower uterine segment involvement, SqD, and Ki-67 index with p<0.25 in the univariate logistic regression analysis were included in the multivariate analysis. Ki-67 was statistically significant in multivariate analysis (p = 0.018); however, there was no statistical significance in SqD and other parameters. Our data suggest that the Ki-67 index rather than SqD needs to be assessed for recurrence in patients with low- and intermediate-risk EEC.

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Author Biographies

Birol Ocak, Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Fatma Öz Atalay, Department of Surgical Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Surgical Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey

Ahmet Bilgehan Sahin, Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Mine Ozsen, Department of Surgical Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Surgical Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey

Bahar Dakiki, Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

Seray Türe, Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

Merve Mesohorli, Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

Hikmet Utku Odman , Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Internal Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey

Özgür Tanrıverdi, Department of Medical Oncology, Faculty of Medicine, Sitki Kocman University, Mugla, Turkey

Department of Medical Oncology, Faculty of Medicine, Sitki Kocman University, Mugla, Turkey

Gökhan Ocakoğlu, Department of Biostatistics, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Biostatistics, Faculty of Medicine, Uludag University, Bursa, Turkey

Hakan Ozan, Department of Gynecologic Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Gynecologic Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Candan Demiröz, Department of Radiation Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Radiation Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Seda Sali, Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Sibel Oyucu Orhan , Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Adem Deligönül, Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Erdem Cubukcu, Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

Department of Medical Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey

The impact of Ki-67 index, squamous differentiation and several clinicopathologic parameters on the recurrence of low and intermediate-risk endometrial cancer
Published
2021-02-18
How to Cite
1.
Ocak B, Atalay F Öz, Sahin AB, Ozsen M, Dakiki B, Türe S, Mesohorli M, Odman HU, Tanrıverdi Özgür, Ocakoğlu G, Bayrak M, Ozan H, Demiröz C, Sali S, Orhan SO, Deligönül A, Cubukcu E, Evrensel T. The impact of Ki-67 index, squamous differentiation, and several clinicopathologic parameters on the recurrence of low and intermediate-risk endometrial cancer. Bosn J of Basic Med Sci [Internet]. 2021Feb.18 [cited 2021Jun.18];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/5437
Section
Pathology